Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) can inhibit cell growth and metastasis, and induce cell apoptosis in cancerous cells. They have been shown to reduce incidence and mortality of gastric cancer by an unknown mechanism. NSAIDs often exert their effects by Cox-2 inhibition, and Cox-2 is overexpressed in gastric cancer cells. Nevertheless, when gastric cancer cells were treated with different NSAIDs, the non-Cox-2-inhibiting R-flurbiprofen was most effective at reducing proliferation of gastric cancer cells in vitro. R-Flurbiprofen prevented the metastatic characteristics of gastric cancer cells in vitro, and reduced tumor size and metastasis in vitro, when gastric cancer cells were injected into nude mice. R-Flurbiprofen also affected multidrug resistance, increasing the sensitivity of resistant gastric cancer cells to chemotherapeutic agents. Mechanistically, R-flurbiprofen was found to have pleiotropic effects, changing levels of cell cycle factors like Cyclin D1 and CKD4, apoptotic protwins like caspase3 and Bcl-2, and protwins that affect metastasis, like metalloproteases. Consistent with reports on other cancer cell types, NSAID treatment with R-flurbiprofen increased levels of the tumor suppressor neurotrophin re...Continue Reading
References
Nov 1, 1992·British Journal of Cancer·H YamaueS Iwakura
Feb 19, 2000·Life Sciences·W J WechterJ D McCracken
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Seigou AbiruKatsumi Eguchi
Jun 28, 2002·The Journal of Biological Chemistry·Mei-Ren Pan, Wen-Chun Hung
Nov 1, 2002·Pancreas·Hiroki YamaueKazuhisa Uchiyama
May 22, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabine GröschGerd Geisslinger
Feb 21, 2004·Biochemical and Biophysical Research Communications·Yanglin PanDaiming Fan
Sep 3, 2004·Cancer Research·Fatima KhwajaDaniel Djakiew
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Jingping DuDaiming Fan
Dec 2, 2004·Journal of the National Cancer Institute·Xiangguo LiuShi-Yong Sun
Aug 11, 2005·The Journal of Clinical Endocrinology and Metabolism·Maria Chiara ZatelliEttore C degli Uberti
Sep 20, 2005·Molecular Cancer Therapeutics·He-Kyung KangSoo-Jeong Lim
Jan 13, 2006·FEBS Letters·Michael M Gottesman, Victor Ling
Jun 22, 2006·Journal of the National Cancer Institute·Maen AbdelrahimStephen Safe
Jul 11, 2006·European Journal of Gastroenterology & Hepatology·Wai K Leung, Joseph J Y Sung
Sep 29, 2006·The Journal of Pharmacology and Experimental Therapeutics·Azza A K El-SheikhFrans G M Russel
Nov 14, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jens van WijngaardenClemens W G M Löwik
Apr 6, 2007·Cancer Research·Emily J QuannDaniel Djakiew
Apr 21, 2007·Cancer Chemotherapy and Pharmacology·Peter AndrewsMelissa Chang
May 19, 2007·Molecular Cancer Research : MCR·Haifeng JinDaiming Fan
May 19, 2007·Cancer Research·Ornella FantappièRoberto Mazzanti
Jul 3, 2007·Neoplasia : an International Journal for Oncology Research·Haifeng JinDaiming Fan
Jul 27, 2007·Toxicology·Chiung-Huei PengChau-Jong Wang
Aug 21, 2007·Anti-cancer Drugs·Libin HuangChengwei Tang
Dec 7, 2007·Cancer Research·Emily J QuannDaniel Djakiew
Apr 1, 2008·Cellular Signalling·Mei-Ren PanWen-Chun Hung
Oct 18, 2008·The Kaohsiung Journal of Medical Sciences·Wen-Chun Hung
Nov 1, 2008·Molecular Cancer Therapeutics·Fatima S KhwajaDaniel Djakiew
Dec 19, 2008·BMC Cancer·Xianling GuoLixin Wei
Jun 9, 2009·Archives of Biochemistry and Biophysics·Xiuling ChiHsin-Hsiung Tai
Citations
Dec 7, 2010·Journal of Materials Science. Materials in Medicine·Saurabh VijayDipak K Majumdar
Nov 26, 2010·Molecular Cancer Research : MCR·Shehla Wynne, Daniel Djakiew
Oct 14, 2014·Drug and Chemical Toxicology·Taygun Timocin, Hasan B Ila
Jan 8, 2016·Drug and Chemical Toxicology·Taygun TimocinMehmet Topaktas
Mar 9, 2013·Journal of Proteomics·Kai LiDaiming Fan
Jan 7, 2015·Applied Biochemistry and Biotechnology·Tomasz SiódmiakMichał Piotr Marszałł
Aug 1, 2014·Chirality·Adam SikoraMichał Piotr Marszałł
Mar 3, 2011·Bioscience Reports·Michele Carrett-DiasGilma Santos Trindade
Sep 7, 2021·Frontiers in Oncology·Meng-Jie ShanYa-Bin Liu