R-plasmid transfer and its response to nalidixic acid.

Journal of Bacteriology
L G Burman

Abstract

The conjugational transfer efficiency of 41 wild-type R-plasmids was studied in Escherichia coli K-12. Type I R-plasmids were transferred at comparatively high and rather uniform frequencies, whereas type F R-plasmids showed less uniform and, on average, somewhat lower transfer frequencies. R-plasmids not mediating sensitivity to F-, I-, or N-specific phages showed moderate transfer frequencies, and type N R-plasmids showed very low transfer frequencies. Various lines of evidence suggest that a well-expressed, but functionally inefficient, conjugation apparatus is the cause of the poor transfer of type N R-plasmids in liquid medium. Nalidixic acid efficiently inhibited transfer of type I and particularly type F R-plasmids, whereas the transfer of type N plasmids was resistant to the drug. Type F and type I plasmids appear to depend on at least one host function for their transfer, namely, the nalidixic acid-sensitive reaction in vegetative chromosome replication, whereas type N plasmids are independent of this function.

References

Apr 15, 1976·Nature·G C Crumplin, J T Smith
Jul 10, 1975·Molecular & General Genetics : MGG·S Dennison, S Baumberg
Oct 1, 1973·Antimicrobial Agents and Chemotherapy·G J BourguignonR Sternglanz
Jan 1, 1968·Molecular & General Genetics : MGG·S E BreslerA A Lukjaniec-Blinkova
Oct 1, 1967·Journal of General Microbiology·Y NishimuraY Hirota
Jan 1, 1969·Journal of Bacteriology·J V BoyleW A Goss
Jan 1, 1968·Cold Spring Harbor Symposia on Quantitative Biology·K W Fisher, M B Fisher
Jan 1, 1968·Cold Spring Harbor Symposia on Quantitative Biology·A CohenH I Adler
Jun 1, 1970·Journal of Bacteriology·N Bouck, E A Adelberg
Jan 1, 1970·Molecular & General Genetics : MGG·J E Dowman, G G Meynell
Nov 26, 1971·Nature·N Datta, R W Hedges
Apr 1, 1972·Virology·H KhatoonV N Iyer
Nov 1, 1965·Genetical Research·S Hollom, R H Pritchard
May 27, 1967·Nature·E Meynell, N Datta

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Citations

Dec 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J S Wolfson
Jul 23, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mariem SaidaniMarisa Haenni
Apr 1, 1989·Journal of Bacteriology·D C HooperM N Swartz
Oct 1, 1985·Antimicrobial Agents and Chemotherapy·J S Wolfson, D C Hooper
Oct 1, 1989·Clinical Microbiology Reviews·J S Wolfson, D C Hooper
Jan 1, 1993·International Journal of Antimicrobial Agents·A Bryskier
Apr 1, 1987·Antimicrobial Agents and Chemotherapy·J Weisser, B Wiedemann
Feb 28, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Apostolos GeorgopoulosWolfgang Graninger

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