R(+)-Thioctic Acid Effects on Oxidative Stress and Peripheral Neuropathy in Type II Diabetic Patients: Preliminary Results by Electron Paramagnetic Resonance and Electroneurography

Oxidative Medicine and Cellular Longevity
Simona Mrakic-SpostaMaristella Gussoni

Abstract

Diabetic neuropathy is the most common complication of diabetes. The idea of alterations in energy metabolism in diabetes is emerging. The biogenic antioxidant R(+)-thioctic acid has been successfully used in the treatment of diabetic polyneuropathic (DPN) patients. The effects of R(+)-thioctic acid (1 tablet, 1.6 g) administration were evaluated in 12 DPN patients at baseline and at 15, 30, 60, and 120 administration days throughout the assessment of oxidative stress (OxS); ROS production rate by electron paramagnetic resonance (EPR) technique; and oxidative damage biomarkers (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PC)), electroneurography (ENG) and visual analogue scale. Supplementation induced significant changes (p < 0.05) at 30 and 60 days. ROS production rate up to -16%; TBARS (-31%), PC (-38%), and TAC up to +48%. Motor nerve conduction velocity in SPE and ulnar nerves (+22% and +16%) and sensor conduction velocity in sural and median nerves (+22% and +5%). Patients reported a general wellness sensation improvement (+35%) at 30 days: lower limb pain sensation (-40%) and upper limbs (-23%). The results strongly indicate that an increased antioxidant capacity plays an important role in OxS, ...Continue Reading

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Citations

Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Sávio Monteiro Dos SantosMarta Chagas Monteiro
Feb 7, 2020·Antioxidants·Pavlina Andreeva-GatevaRadka Tafradjiiska-Hadjiolova
Aug 28, 2021·Current Diabetes Reports·Tina Okdahl, Christina Brock

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Methods Mentioned

BETA
amputation

Software Mentioned

Win EPR System
GraphPad Prism
Freeware G ∗ Power

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