PMID: 9539805May 16, 1998Paper

R-type Ca2+ currents evoke transmitter release at a rat central synapse

Proceedings of the National Academy of Sciences of the United States of America
L G WuB Sakmann

Abstract

Voltage-dependent Ca2+ currents evoke synaptic transmitter release. Of six types of Ca2+ channels, L-, N-, P-, Q-, R-, and T-type, only N- and P/Q-type channels have been pharmacologically identified to mediate action-potential-evoked transmitter release in the mammalian central nervous system. We tested whether Ca2+ channels other than N- and P/Q-type control transmitter release in a calyx-type synapse of the rat medial nucleus of the trapezoid body. Simultaneous recordings of presynaptic Ca2+ influx and the excitatory postsynaptic current evoked by a single action potential were made at single synapses. The R-type channel, a high-voltage-activated Ca2+ channel resistant to L-, N-, and P/Q-type channel blockers, contributed 26% of the total Ca2+ influx during a presynaptic action potential. This Ca2+ current evoked transmitter release sufficiently large to initiate an action potential in the postsynaptic neuron. The R-type current controlled release with a lower efficacy than other types of Ca2+ currents. Activation of metabotropic glutamate receptors and gamma-aminobutyric acid type B receptors inhibited the R-type current. Because a significant fraction of presynaptic Ca2+ channels remains unidentified in many other central ...Continue Reading

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Citations

Sep 17, 1999·Muscle & Nerve·D A Greenberg
Aug 26, 2006·Cell and Tissue Research·Hans-Christian Kornau
Mar 9, 2004·Journal of Neuroscience Methods·Jian-Yuan SunLing-Gang Wu
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