Abstract
Primary liver cancer constitutes an increasingly malignancy in the Western world and one of the leading causes of cancer-related deaths worldwide. The purpose of this study was to evaluate and compare long-term outcomes after R0 resections in noncirrhotic livers for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Between April 1998 and May 2006 a total of 102 patients with either ICC (n = 41, group 1) or HCC (n = 61, group 2) in the absence of cirrhosis underwent curative liver resection in our department. Demographic characteristics, operative details, perioperative complications, pathologic findings, tumor recurrence and survival were analyzed. Gender (P = 0.007), extent of liver resection (P = 0.036), additional surgical procedures (P < 0.001) and operative morbidity (P = 0.018) differed among the two groups. Following resection, after a median follow-up of 28 months, the calculated 5-year survival was 44% and 40% for ICC and HCC, respectively (P = 0.38). The corresponding recurrence-free survival was 25% for both ICC and HCC (P = 0.66). UICC stage was found to predict overall and recurrence-free survival in both types of tumors. Multifocality in the case of ICC, and tumor differentiation and vascul...Continue Reading
References
Mar 1, 1995·Archives of Surgery·W K WashburnR L Jenkins
Oct 1, 1995·Archives of Surgery·D CherquiP L Fagniez
Jan 1, 1995·World Journal of Surgery·R PichlmayrB Ringe
Nov 1, 1996·Annals of Surgery·S KoH Nakano
Nov 1, 1996·The British Journal of Surgery·S V BerdahY P Le Treut
Jan 28, 1998·Annals of Surgery·J R MadariagaT E Starzl
Oct 23, 1998·Journal of the American College of Surgeons·S RoayaieM E Schwartz
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M LlovetJ Bruix
Dec 22, 1999·The British Journal of Surgery·S TakanoS Iwai
Apr 5, 2000·Annals of Surgery·R T PoonJ Wong
Oct 24, 2002·Journal of Clinical Gastroenterology·Hashem B El-Serag
Oct 28, 2004·Gastroenterology·F Xavier BoschRamon Cléries
Dec 29, 2004·Annals of Surgery·Hauke LangChristoph E Broelsch
Mar 14, 2007·The American Journal of Medicine·Sameer Parikh, David Hyman
Jul 10, 2007·Journal of the American College of Surgeons·Hauke LangChristoph E Broelsch
Citations
Feb 5, 2011·Der Anaesthesist·S HerzC von Heymann
Jan 8, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xianwu LuoGongtian Wei
Feb 19, 2010·Langenbeck's Archives of Surgery·Frank SimonFrank Weber
Mar 7, 2012·Langenbeck's Archives of Surgery·Jennifer LaFemina, William R Jarnagin
Jul 20, 2010·The Surgical Clinics of North America·George A PoultsidesTimothy M Pawlik
Jul 29, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jan LerutRobert J Porte
Apr 1, 2014·Journal of Hepatology·John BridgewaterGregory J Gores
Jun 20, 2015·Gastroenterology Research and Practice·Kelly J LafaroTimothy M Pawlik
Apr 5, 2012·Scandinavian Journal of Gastroenterology·Marcus A WörnsGerd Otto
Jan 20, 2012·Annals of Surgery·Brian ShragerSasan Roayaie
May 10, 2020·Journal of Clinical Medicine·Enrico GringeriFrancesco Paolo Russo
Feb 3, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Nikolaos MachairasGeorgios C Sotiropoulos
Mar 2, 2021·Annals of Surgical Oncology·Zhi Ven FongKenneth K Tanabe
Aug 20, 2019·Surgery·Tomoaki YohOlivier Soubrane