Rab GTPase Function in Endosome and Lysosome Biogenesis

Trends in Cell Biology
Lars LangemeyerChristian Ungermann

Abstract

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates the protein and lipid content of the plasma membrane, it participates in the intracellular quality control machinery and is needed for the efficient removal of damaged organelles. This complex network comprises an endosomal membrane system that feeds into the lysosomes, yet also allows recycling of membrane proteins, and probably lipids. Moreover, lysosomal degradation provides the cell with macromolecules for further growth. In this review, we focus primarily on the role of the small Rab GTPases Rab5 and Rab7 as organelle markers and interactors of multiple effectors on endosomes and lysosomes and highlight their role in membrane dynamics, particularly fusion along the endolysosomal pathway.

Citations

Aug 21, 2019·Cells·Noemi Antonella Guadagno, Cinzia Progida
Oct 4, 2019·The New Phytologist·Anna M G Novák VanclováVladimír Hampl
Nov 7, 2019·Journal of Neurochemistry·Susanna CogoElisa Greggio
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Cecilia Rodriguez-FurlanGlenn R Hicks
Nov 23, 2019·Communications Biology·Makoto NaganoJiro Toshima
Dec 25, 2019·Molecular & Cellular Proteomics : MCP·Wayne M JurickBret Cooper
Feb 28, 2020·Journal of Fungi·Christiane RollenhagenSamuel A Lee
May 12, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Amrita PathakBruce D Carter
May 12, 2020·ELife·Lars LangemeyerChristian Ungermann
Jul 15, 2020·ELife·Md Rakibul HasanDavid Pc Rice
Nov 9, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yanhao ZhangNing Gao
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ming SunYue Sun
Jun 6, 2020·Journal of Cell Science·Lena DehnenAchim Paululat
Jul 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Hersh K BhargavaJames H Hurley
Jun 21, 2019·Journal of Leukocyte Biology·Kensuke MiyakeYusuke Murakami
Jun 6, 2020·Journal of Cell Science·Åsa B Birgisdottir, Terje Johansen
Jun 30, 2019·The Journal of Cell Biology·ShiYu WangAvital A Rodal
Jul 29, 2020·Frontiers in Cell and Developmental Biology·Logan R Hurst, Rutilio A Fratti
Mar 31, 2019·Nature Communications·Aysegul SapmazHuib Ovaa
Aug 6, 2019·Frontiers in Cellular Neuroscience·Gaurav DattaXuesong Chen
Apr 23, 2020·International Journal of Molecular Sciences·Mitsuhiro HoshijimaMasaharu Takigawa
Sep 24, 2020·Journal of Neurochemistry·Melina OverhoffNatalia L Kononenko
Oct 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gülçin TezcanSvetlana F Khaiboullina
Oct 24, 2020·Molecular and Cellular Biochemistry·Wenyi ZhouShaojun Liu
Dec 17, 2020·American Journal of Physiology. Cell Physiology·Fiona J McDonald
Sep 15, 2020·Journal of Experimental Botany·Ying-Ping HuangChi-Ping Cheng
Dec 18, 2020·Journal of Medical Virology·Juan Luis Gomez MartiAdam M Brufsky
Dec 30, 2020·Journal of Neurochemistry·Marijn KuijpersTolga Soykan
Nov 5, 2019·Journal of Molecular Biology·Péter Lőrincz, Gábor Juhász

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cell Science
Henning J kleine Balderhaar, Christian Ungermann
Biocell : Official Journal of the Sociedades Latinoamericanas De Microscopía Electronica ... Et. Al
M A BarbieriP D Stahl
Current Opinion in Cell Biology
Daniel Kümmel, Christian Ungermann
Journal of Genetics and Genomics = Yi Chuan Xue Bao
Jia-Jia Liu
Bioarchitecture
Riddhi Atul JaniSubba Rao Gangi Setty
© 2022 Meta ULC. All rights reserved