Rabbit erythrocyte band 3: a receptor for staphylococcal alpha toxin

Canadian Journal of Microbiology
I Maharaj, H B Fackrell

Abstract

Enzymes known to specifically cleave the band 3 component of the rabbit erythrocyte membrane were found to reduce both the hemolytic sensitivity to and the binding of the alpha toxin of Staphylococcus aureus. Lectins which bind to band 3 also inhibited the toxin. Lectins which do not bind to band 3 have no effect. Purified band 3, isolated by affinity chromatography on a concanavalin A column, was homogeneous by polyacrylamide gel electrophoresis, had a molecular weight of 100 000, and inhibited the hemolytic activity of alpha toxin. Antibodies to the toxin-toxoid receptor were serologically indistinguishable from antiband 3.

Citations

Jan 1, 1988·Toxicon : Official Journal of the International Society on Toxinology·M Thelestam, L Blomqvist
Jan 1, 1982·Pharmacology & Therapeutics·J H Freer, J P Arbuthnott
Apr 18, 2013·Biochimica Et Biophysica Acta·M SchwieringN Hellmann
Aug 2, 2005·International Journal of Cardiology·Khalid AlmutiRobert J Ostfeld
Dec 18, 1987·Biochimica Et Biophysica Acta·T E Hebert, H B Fackrell
Jul 25, 1984·Biochimica Et Biophysica Acta·J W Austin, H B Fackrell
Dec 1, 1991·Microbiological Reviews·S Bhakdi, J Tranum-Jensen

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