PMID: 6412231Sep 1, 1983Paper

Rabbit immunoglobulin kappa genes: structure of a germline b4 allotype J-C locus and evidence for several b4-related sequences in the rabbit genome

Proceedings of the National Academy of Sciences of the United States of America
L EmorineE E Max

Abstract

To investigate the genetic mechanism by which certain rabbits can express immunoglobulins unexpected on the basis of their pedigree (i.e., "latent" allotypes), we have begun a study of the rabbit immunoglobulin kappa gene locus. Here we report the structure of a germline genomic clone that encodes the b4 allotype of rabbit kappa immunoglobulin and corresponds to the kappa gene expressed by the rabbit-mouse hybridoma 12F2. The nucleotide sequences of the joining (J) and constant (C) regions reveal structures generally similar to the homologous mouse and human loci, although only one of the five J-like sequences of this rabbit gene is apparently expressed. Southern blotting analysis of DNA from several rabbit allotypic strains by using probes derived from the cloned b4 gene demonstrates that, in contrast to mouse and human, rabbits possess multiple kappa-related sequences. Rabbits of the nominal b4, b5, b6, and b9 allotypes each contain at least two b4-related sequences that are associated with their own J regions and that are highly homologous to the cloned b4 gene in both coding and flanking regions.

References

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Citations

Feb 19, 2000·Biochemical and Biophysical Research Communications·Y LiG C Whitelam
Jan 1, 1987·Immunogenetics·G A GutmanP R Baverstock
Jan 1, 1984·Immunogenetics·R G MageA S Kelus
Jan 1, 1985·Developmental and Comparative Immunology·T Matsunaga
Apr 1, 1987·Molecular Immunology·N McCartney-FrancisR G Mage
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L EmorineE E Max
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S Karlin, G Ghandour
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L G FineS Salehmoghaddam
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C I Wu, W H Li
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A AkimenkoF Rougeon
Nov 18, 2011·Veterinary Immunology and Immunopathology·Stefanie HaraClaus-Peter Czerny
Jul 30, 2015·Developmental and Comparative Immunology·Stefanie WaltherClaus-Peter Czerny
Aug 1, 1993·European Journal of Immunology·L A BovkunA V Taranin

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