PMID: 3757546Aug 1, 1986Paper

Rabbit ocular and pineal autoimmune response to retina antigens

Current Eye Research
C M Kalsow, W B Wacker

Abstract

Different forms of experimental autoimmune uveitis (EAU) can be produced by varying protocols to present different autoantigens to several species of experimental animal. We have studied the clinical, histological and serological responses of rabbits to footpad injection of various fractions of retina extract. Rabbits injected with retina extract or S antigen developed posterior uveitis. However, rabbits injected with retina extract, also developed an anterior uveitis and pinealitis not seen in rabbits receiving S antigen. The Serological response of rabbits to retina extract was different than that to purified S antigen. Antisera of rabbits receiving retina extract reacted with rabbit retina and pineal gland as well as with guinea pig retina but not with guinea pig pineal gland. In contrast anti-S antigen sera reacted with rabbit retina and guinea pig retina and pineal gland but not with rabbit pineal gland. Gel filtration chromatography of the ammonium sulfate supernate of retina extract was used to differentiate the antigens with which these two sera reacted. An analysis of these experiments gives preliminary evidence of an autoantigen(s) of rabbit retina and pineal gland that is not S antigen. The existence of multiple auto...Continue Reading

References

Jan 1, 1974·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·K D SchröderS Tilgner
Jan 1, 1974·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·S TilgnerK D Schröder
Jan 1, 1973·International Archives of Allergy and Applied Immunology·C M Kalsow, W B Wacker
Jan 1, 1973·Experimental Eye Research·S TilgnerK D Schröder
Aug 1, 1968·Archives of Ophthalmology·S B Aronson
Aug 1, 1982·American Journal of Ophthalmology·R B NussenblattA E Maumenee

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Citations

Jan 1, 1988·Eye·A ShallalS al-Mahdawi
Jun 20, 2007·The British Journal of Ophthalmology·Farzin ForooghianJ Raymond Buncic
Jan 1, 1993·The British Journal of Ophthalmology·C M KalsowT P Nifong
Jan 1, 1995·Ocular Immunology and Inflammation·P A GollinC M Kalsow
Jan 1, 1992·Current Eye Research·C M KalsowT P Nifong
Jan 1, 1992·Current Eye Research·H S DuaL A Donoso

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