Rabbit translation elongation factor 1 alpha stimulates the activity of homologous aminoacyl-tRNA synthetase

FEBS Letters
B S NegrutskiiA V El'Skaya

Abstract

Functional and structural sequestration of aminoacyl-tRNA has been recently found in eukaryotic cells and the aminoacyl-tRNA channeling has been suggested [B.S. Negrutskii et al., Proc. Natl. Acad. Sci. 91 (1994) 964-968], but molecular details and mechanism of the process remained unclear. In this paper we have verified a possible interaction between rabbit aminoacyl-tRNA synthetase and homologous translation elongation factor 1 alpha (EF-1 alpha), the proteins which may play a role of sequential components involved in the transfer of the aminoacyl-tRNA along the protein synthetic metabolic chain. The stimulation of the phenylalanyl-tRNA synthetase activity by EF-1 alpha is found. The effect is shown to be specific towards the origin of tRNA and elongation factor molecules. The data obtained favor the direct transfer mechanism of the aminoacyl-tRNA channeling process during eukaryotic protein synthesis.

References

May 24, 1979·Biochimica Et Biophysica Acta·D W SmithA L McNamara
Jan 1, 1979·Methods in Enzymology·K Iwasaki, Y Kaziro
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S Negrutskii, M P Deutscher
Jan 1, 1991·Progress in Nucleic Acid Research and Molecular Biology·M Mirande
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B S Negrutskii, M P Deutscher
Jan 1, 1987·Annual Review of Biochemistry·P A Srere
Nov 28, 1986·Science·D K Srivastava, S A Bernhard
Jun 29, 1981·FEBS Letters·L Dibbelt, H G Zachau
May 1, 1994·Molecular Biology Reports·C G Proud
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·B S NegrutskiiM P Deutscher
Jun 19, 1962·Biochemical and Biophysical Research Communications·E F BRUNNGRABER

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Citations

Feb 7, 2002·Biochemical and Biophysical Research Communications·Jong Sang LeeSunghoon Kim
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·T O LukashA V El'skaya
Mar 21, 1998·Journal of Biochemical and Biophysical Methods·B GarroneD Watters
Jun 23, 1998·Trends in Genetics : TIG·M Hafezparast, E Fisher
May 24, 2003·Cold Spring Harbor Symposia on Quantitative Biology·G R Andersen, J Nyborg
Oct 30, 2018·Human Mutation·Fiona McLachlanCatherine M Abbott
Nov 30, 2006·Molecular and Cellular Biochemistry·Marie-Pierre Golinelli-Cohen, Marc Mirande
Oct 6, 1997·The Journal of Biological Chemistry·R StapulionisM P Deutscher
Aug 3, 2004·Journal of Cell Science·Sang Won LeeSunghoon Kim
Apr 10, 2003·Biochemical and Biophysical Research Communications·Jung Min HanSunghoon Kim

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