RabGEF1 is a negative regulator of mast cell activation and skin inflammation

Nature Immunology
See-Ying TamS J Galli

Abstract

Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways in Fc epsilon RI-dependent mast cell activation. RabGEF1-deficient mast cells showed enhanced degranulation and release of lipid mediators and cytokines in response to Fc epsilon RI aggregation. RabGEF1-deficient mice developed severe skin inflammation and had increased numbers of mast cells. Thus, RabGEF1 is a negative regulator of Fc epsilon RI-dependent mast cell activation, and a lack of RabGEF1 results in the development of skin inflammation in vivo.

References

Feb 1, 1992·Immunological Reviews·H Metzger
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J ColicelliM Wigler
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J D YoungS J Galli
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·V S PribludaH Metzger
Dec 1, 1996·Current Opinion in Immunology·M A Beaven, R A Baumgartner
Feb 1, 1997·Current Opinion in Genetics & Development·M E Katz, F McCormick
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·O El-HillalA M Scharenberg
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·L HanJ Colicelli
Nov 14, 1997·Physiological Reviews·D D MetcalfeY A Mekori
May 30, 1998·The Journal of Biological Chemistry·K Liu, G Li
Jul 25, 1998·The Journal of Biological Chemistry·M A BarbieriP D Stahl
Feb 27, 1999·Current Opinion in Immunology·S J GalliC S Lantz
May 18, 1999·The Journal of Biological Chemistry·H HamaB F Horazdovsky
Jun 8, 1999·Annual Review of Immunology·J P Kinet
Dec 23, 1999·Current Opinion in Hematology·S J Galli
Mar 17, 2000·Immunological Reviews·Y A Mekori, D D Metcalfe
Mar 31, 2000·Trends in Cell Biology·J M ShieldsC J Der
Jun 8, 2000·Immunity·S SaitohL E Samelson
Jun 23, 2001·Immunity·K AsaiT Kawakami
Jul 20, 2001·Cell·P P Di Fiore, P De Camilli
Dec 26, 2001·The Journal of Biological Chemistry·Kota SaitoToshiaki Katada
Jan 11, 2002·Molecular and Cellular Biology·Ying WangJohn Colicelli
Jun 29, 2002·Nature Immunology·Valentino ParraviciniJuan Rivera
Oct 3, 2002·Nature Reviews. Immunology·Toshiaki Kawakami, Stephen J Galli
Nov 5, 2002·Current Opinion in Immunology·Juan Rivera
Jul 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yuko KawakamiToshiaki Kawakami
Oct 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jiro KitauraToshiaki Kawakami
Nov 25, 2003·Current Opinion in Immunology·Reuben P Siraganian

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Citations

May 15, 2007·Immunologic Research·Ming ZhangDevendra K Agrawal
Dec 21, 2007·Clinical Reviews in Allergy & Immunology·Daniel NaviFu-Tong Liu
Jan 21, 2011·Clinical Reviews in Allergy & Immunology·Fu-Tong LiuHuan-Yuan Chen
Oct 22, 2008·Nature Immunology·Janet Kalesnikoff, Stephen J Galli
Apr 24, 2007·Nature Structural & Molecular Biology·Anna Delprato, David G Lambright
Jun 16, 2005·The Journal of Experimental Medicine·Charlotte L WellerTimothy J Williams
Dec 7, 2005·The Journal of Experimental Medicine·Julie WhewayFabienne Mackay
Aug 19, 2007·Molecular Biology of the Cell·Huaiping ZhuGuangpu Li
Mar 18, 2005·Annual Review of Immunology·Stephen J GalliMindy Tsai
Aug 2, 2013·Cell Communication and Signaling : CCS·Lan K NguyenBoris N Kholodenko
Mar 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Janet KalesnikoffStephen J Galli
Feb 4, 2014·Pharmacology & Therapeutics·Laurent L Reber, Nelly Frossard
Jan 3, 2009·Experimental Cell Research·Adriana GalvisM Alejandro Barbieri
Aug 30, 2008·Clinics in Dermatology·Yi-Yang Yvonne LiMichael P Schön
Sep 6, 2008·The EMBO Journal·Rafael Mattera, Juan S Bonifacino
Jun 15, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takuma IshizakiAkihiko Yoshimura
Feb 12, 2010·Annals of the New York Academy of Sciences·Prabir RayAnuradha Ray
Jan 18, 2006·Biochemical and Biophysical Research Communications·C M HunkerM A Barbieri
Jul 27, 2010·Current Biology : CB·Lizhong XuDafna Bar-Sagi
Aug 10, 2010·Current Biology : CB·John Colicelli
May 2, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Tze Khee ChanW S Fred Wong
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·David MillrineTadamitsu Kishimoto
Nov 8, 2016·The Journal of Clinical Investigation·Thomas MarichalStephen J Galli
Nov 15, 2014·Cells·Zoi ErpapazoglouRosine Haguenauer-Tsapis
Oct 28, 2016·Nature Communications·Kwok Ho YipMichele A Grimbaldeston
Apr 18, 2007·Nature Reviews. Immunology·Stefan Kraft, Jean-Pierre Kinet
Dec 17, 2009·Expert Opinion on Therapeutic Targets·Satoshi Tanaka
Feb 18, 2016·EMBO Molecular Medicine·Maria Francesca BaiettiAnna A Sablina
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Waleed F KhalafD Wade Clapp
Jun 2, 2016·Cell Structure and Function·Morié IshidaMitsunori Fukuda
Nov 15, 2015·Journal of Cell Science·Theresa A Reimels, Cathie M Pfleger

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