PMID: 558341Apr 1, 1977Paper

Rabies virus protein synthesis in infected BHK-21 cells

Journal of Virology
H P Madore, J M England

Abstract

Rabies virus specific polypeptide synthesis was examined under hypertonic conditions, which selectively inhibit cellular protein synthesis. The rabies virus proteins (L, G, N, M1, M2) were synthesized throughout the course of infection, with little change in their relative rates of synthesis. The rates of synthesis of the G and M1 polypeptides were more sensitive to increasing osmolarity than those of the L, N, and M2 polypeptides. Extrapolation to isotonicity of the results obtained under hypertonic conditions indicated that the molar ratios of the polypeptides synthesized under normal conditions were 0.4 (L), 64 (G), 100 (N), 75 (M1) and 35 (M2). A high-molecular-weight polypeptide (190,000), designated polypeptide L, was repeatedly detected both in infected cells and in extracellular virus. The estimated number of L polypeptide molecules per virion was 33. The synthesis of a viral glycoprotein precursor, designated gp78, , preceded the appearance of the mature viral glycoprotein in infected cells labeled with [3H]glucosamine under isotonic conditions. In cells labeled under hypertonic conditions, little or no mature viral glycoprotein was detected, but a virus-specific glycoprotein with an electrophoretic mobility similar to...Continue Reading

References

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Citations

Apr 5, 2005·Journal of Neurovirology·Zhen F Fu, Alan C Jackson
Jul 7, 2007·Memórias do Instituto Oswaldo Cruz·Myriam L VelandiaJaime E Castellanos
Mar 21, 2006·Microbiology and Immunology·Junji Hosokawa-MutoNobuyuki Minamoto
Jan 20, 2021·Cellular and Molecular Neurobiology·Soheil GhassemiMohammad Sayyah
Feb 7, 2021·International Journal of Molecular Sciences·Junyan QuZhenghong Lin
Jun 18, 2017·Turkish Journal of Medical Sciences·Veysel KayserBernhardt L Trout
Sep 12, 2017·Frontiers in Cellular Neuroscience·Vibhuti JoshiAmit Mishra
Jan 1, 1982·Comparative Immunology, Microbiology and Infectious Diseases·F Bussereau, P Perrin
Nov 1, 1978·Journal of Virology·A Flamand, J F Delagneau
Mar 1, 1979·Journal of Virology·V M ZaidesV M Zhdanov
Oct 1, 1980·Journal of Virology·W H WunnerT J Wiktor
Jun 1, 1984·Journal of Virology·M G KurillaJ D Keene
Mar 1, 1987·Microbiological Reviews·A K Banerjee
Jul 1, 1979·Journal of Virology·N Saghi, A Flamand
Jun 1, 1980·Virology·D PennicaJ F Obijeski
Nov 1, 1978·Virology·S Naito, S Matsumoto
Aug 31, 1981·Biochemical and Biophysical Research Communications·P Münzel, K Koschel

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