Rac GTPases in erythroid biology.

Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
D G KonstantinidisTheodosia A Kalfa

Abstract

Rac1 and Rac2 GTPases, members of the Rho GTPases family, control actin organization and play distinct and overlapping roles in hematopoietic and mature blood cells of all lineages. Here, we review our findings on the role of Rac GTPases in erythroid cells, by using conditional gene-targeting in mice. Rac1 and Rac2 deficiency causes anemia with reticulocytosis, indicating decreased red blood cell (RBC) survival, altered actin assembly in the erythrocyte membrane skeleton and decreased RBC deformability. On the other hand, Rac1(-/-); Rac2(-/-) megakaryocyte-erythrocyte progenitors demonstrate decreased proliferation in the bone marrow, but increased survival and proliferation in the spleen, indicating that stress erythropoiesis circumvents Rac GTPases deficiency. Further elucidation of the signaling pathways controlled by Rac GTPases in erythroid cells may reveal potential therapeutic targets for diseases characterized by hemolytic anemia and erythropoiesis disorders.

References

Jul 1, 1992·Molecular and Cellular Biology·S VincentP Fort
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T J Byers, D Branton
Dec 1, 1994·The Journal of Cell Biology·A WeberV M Fowler
Apr 5, 1996·The Journal of Biological Chemistry·P A KuhlmanV M Fowler
Feb 7, 1998·Science·A Hall
May 19, 2000·The Biochemical Journal·A L Bishop, A Hall
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
May 14, 2003·The Journal of Cell Biology·Kurt L BarkalowJohn H Hartwig
Jan 28, 2004·Cell·Keith Burridge, Krister Wennerberg
May 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuan GaoYi Zheng
Oct 29, 2004·Journal of Cell Science·Martin Schwartz
Dec 14, 2004·Blood·Laurie E LenoxRobert F Paulson
Jul 19, 2005·Molecular and Cellular Biology·Veerendra MunugalavadlaReuben Kapur
Jul 19, 2005·Nature Medicine·Jose A CancelasDavid A Williams
Jun 22, 2007·Immunity·Hiromi Iwasaki, Koichi Akashi
Feb 12, 2008·Nature Cell Biology·Peng JiHarvey F Lodish
Nov 8, 2008·Blood·Narla Mohandas, Patrick G Gallagher
Dec 8, 2009·Blood·James C MulloyYi Zheng

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