Abstract
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease. HCV cure has been linked to improved patient outcomes. In the era of direct-acting antivirals (DAAs), HCV cure has become the goal, as defined by sustained virological response 12 weeks (SVR12) after completion of therapy. Historically, African-Americans have had lower SVR12 rates compared to White people in the interferon era, which had been attributed to the high prevalence of non-CC interleukin 28B (IL28B) type. Less is known about the association between race/ethnicity and SVR12 in DAA-treated era. The aim of the study is to evaluate the predictors of SVR12 in a diverse, single-center Veterans Affairs population. We conducted a retrospective study of patients undergoing HCV therapy with DAAs from 2014 to 2016 at the VA Greater Los Angeles Healthcare System. We performed a multivariable logistic regression analysis to determine predictors of SVR12, adjusting for age, HCV genotype, DAA regimen and duration, human immunodeficiency virus (HIV) status, fibrosis, nonalcoholic fatty liver disease (NAFLD) fibrosis score, homelessness, mental health, and adherence. Our cohort included 1068 patients, out of which 401 (37.5%) were White people and 400 (37.5%)...Continue Reading
References
Nov 26, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C NiederauD Häussinger
Mar 11, 1999·The New England Journal of Medicine·H B El-Serag, A C Mason
Jul 25, 2000·JAMA : the Journal of the American Medical Association·D L ThomasD Vlahov
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hugo R RosenDavid J Hinrichs
Apr 2, 2002·The American Journal of Gastroenterology·Thelma E WileyJuliana Chan
May 17, 2006·Annals of Internal Medicine·Gregory L ArmstrongMiriam J Alter
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lisa I BackusLarry A Mole
Jul 11, 2008·Clinical Pharmacology and Therapeutics·S U YasudaS-M Huang
May 1, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Sudeep KarveBradley C Martin
Jul 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adeel A ButtCharity G Moore
Aug 18, 2009·Nature·Dongliang GeDavid B Goldstein
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Eric ChakSammy Saab
May 23, 2012·Alimentary Pharmacology & Therapeutics·A S Rangnekar, R J Fontana
Mar 6, 2013·Annals of Internal Medicine·Rebecca L MorganYngve Falck-Ytter
Aug 22, 2013·The Journal of Infectious Diseases·Genevieve WojcikChloe L Thio
Oct 15, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eric M YoshidaEric Lawitz
Apr 8, 2015·Journal of Hepatology·Sakura AkamatsuKazuaki Chayama
Nov 9, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julius M WilderK Rajender Reddy
Jun 9, 2016·Gastroenterology·George N IoannouKristin Berry
Sep 24, 2016·Clinical and Translational Gastroenterology·Monica A Konerman, Anna S F Lok
Oct 25, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng SuGeorge N Ioannou
Dec 10, 2016·Antiviral Therapy·Lisa I BackusLarry A Mole
Citations
Aug 11, 2018·European Journal of Gastroenterology & Hepatology·Vijay GayamSmruti Mohanty
Dec 13, 2019·Journal of Medical Virology·Michael FuchsDoris Toro
Jan 9, 2019·Hepatology Communications·Tatyana Kushner, Norah A Terrault
Apr 6, 2019·Open Forum Infectious Diseases·Edward R CachayUNKNOWN HCV-TREN Cohort
Feb 1, 2019·World Journal of Gastroenterology : WJG·Murali GanesanNatalia A Osna
Feb 2, 2020·Journal of Racial and Ethnic Health Disparities·Laura D'AnnaUNKNOWN PPOWER Project Team
Mar 18, 2020·Journal of Medical Virology·Luis Margusino-FramiñánÁngeles Castro-Iglesias
Nov 30, 2020·Journal of Viral Hepatitis·Irene Pericot-ValverdeAlain H Litwin
Nov 3, 2020·Clinical Lymphoma, Myeloma & Leukemia·Sanjal H DesaiDawn Fishbein
Nov 29, 2020·Journal of Hepatology·Tatyana Kushner, Nancy Reau
Jan 16, 2021·Open Forum Infectious Diseases·Kristina M BrooksJennifer J Kiser
Jun 17, 2020·The Korean Journal of Internal Medicine·Eun Sun JangSook-Hyang Jeong
Nov 24, 2020·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Ik Sung ChoiSang Goon Shim
Oct 16, 2021·Open Forum Infectious Diseases·Jesse PowellMandana Khalili