Race and prostate weight as independent predictors for biochemical recurrence after radical prostatectomy

Prostate Cancer and Prostatic Diseases
F R SchroeckJudd W Moul

Abstract

We hypothesized that factors beyond pathological stage, grade, PSA and margin status would be important predictors of biochemical recurrence (BCR) after radical prostatectomy (RP). A cohort of 3194 patients who underwent RP between 1988 and 2007 and who had neither neoadjuvant therapy nor postoperative adjuvant hormonal therapy was retrieved from the Duke Prostate Center database. Age, prostate-specific antigen (PSA), pathological Gleason score (pG), lymph node status, seminal vesicle invasion (SVI), extracapsular extension (ECE), positive surgical margin (PSM) status, year of surgery, race, adjuvant radiation therapy (XRT), percent tumor involvement in the RP specimen and prostate weight were evaluated as possible predictors of BCR in multivariate Cox regression analysis. BCR was defined as a PSA of 0.2 ng ml(-1) or higher at least 30 days after surgery. A nomogram was developed from the Cox model. Predictive accuracy was obtained by calculating bias-corrected Harrell's c and by bootstrap calibration. In multivariate analysis, PSA (hazard ratio 1.39 (95% confidence interval 1.29-1.51)), ECE (1.22 (1.04-1.44)), pG score (1.38 (1.14-1.68), 2.23 (1.76-2.84), 2.69 (2.12-3.40) for pG 3+4, 4+3, >7, respectively), SVI (1.72 (1.40-2.1...Continue Reading

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Citations

May 1, 2013·Archives of Pathology & Laboratory Medicine·Oleksandr N KryvenkoJonathan I Epstein
Jun 10, 2011·Journal of Korean Medical Science·In-Chang ChoKang Hyun Lee
Aug 7, 2012·Korean journal of urology·Sun Ho MinHyeon Hoe Kim
Dec 10, 2013·International Journal of Surgical Pathology·Brian D Hayes, Stephen P Finn
Oct 25, 2016·The Prostate·Abra JeffersAlice S Whittemore
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Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eric J WhitmanGyorgy Petrovics

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