Race and sex: predictors of the severity of hyperparathyroidism in peritoneal dialysis patients

Nephrology
Stanley L-S FanMagdi M Yaqoob

Abstract

Uraemic hyperparathyroidism remains a common clinical problem. Conversely, oversuppression of parathyroid hormone (PTH), particularly in diabetic patients on peritoneal dialysis, has been implicated in low bone turnover disease. Race may also be an important factor determining susceptibility to hyperparathyroidism and the different forms of renal osteodystrophy. These compounding factors that might influence the severity of hyperparathyroidism have been studied in US dialysis and predialysis populations. Dialysis-dependant Africans and Afro-Caribbeans (AC) are known to have higher circulating PTH concentrations than comparable Caucasians (C) but Indo-Asians (IA) living in temperate climates have not been studied. We performed a cross-sectional study of all patients undergoing peritoneal dialysis at St Bartholomew's and The Royal London Hospital on 1 May 2000. The highest historical recorded PTH was recorded with concurrent biochemical and demographic details. Regression models were used for the analysis of covariance and separate manova was performed incorporating the factors that were shown on univariate analysis to be significant. The current study confirmed that in 50 AC patients on peritoneal dialysis, the mean (+/- SEM) pe...Continue Reading

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Mar 24, 2007·Nature Reviews. Immunology·Paul R CrockerAjit Varki
Apr 11, 2013·Nephro-urology Monthly·Sidy Mohamed SeckAhmet Ould Lemrabott Tal
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