Race, ethnicity, and cognition in persons newly diagnosed with multiple sclerosis

Neurology
Lilyana AmezcuaAnnette Langer-Gould

Abstract

To determine whether black or Hispanic patients with newly diagnosed multiple sclerosis (MS) are more likely to have cognitive impairment than white patients when compared to controls matched on age, sex, and race/ethnicity. Whether black or Hispanic patients have a more aggressive MS disease course than white patients remains unclear. No prior studies have examined differences in early cognitive impairment. The oral Symbol Digit Modalities Test (SDMT) is sensitive to early cognitive impairment in MS but normative data in nonwhite patients are limited. We studied 1,174 adults who enrolled in the MS Sunshine Study. SDMT and verbal fluency were measured in 554 incident cases of MS or clinically isolated syndrome (CIS) and 620 matched controls. Multivariable regression was used to examine correlates of abnormal SDMT in the entire cohort. The strongest independent predictors of lower oral SDMT scores in rank order were having MS/CIS, lower educational attainment, and being black or Hispanic. Black and Hispanic patients and controls had lower SDMT scores than white participants even after controlling for age, sex, and education. However, no interaction between race/ethnicity and MS case status on SDMT scores was detected. Easy-to-us...Continue Reading

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Citations

Mar 11, 2020·Neurology·Victoria M Leavitt
Sep 20, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Carlos A PérezJohn A Lincoln
Feb 13, 2021·Neuropsychiatric Disease and Treatment·Elizabeth S Gromisch, Zaenab Dhari
Jun 3, 2021·Multiple Sclerosis and Related Disorders·Hamza CobanJaime Imitola

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