Jan 22, 2008

Race, medical researcher distrust, perceived harm, and willingness to participate in cardiovascular prevention trials

Joel B BraunsteinNeil R Powe


Minority underrepresentation exists in medical research including cardiovascular clinical trials, but the hypothesis that this relates to distrust in medical researchers is unproven. Therefore, we examined whether African American persons differ from white persons in perceptions of the risks/benefits of trial participation and distrust toward medical researchers, and whether these factors influence willingness to participate (WTP) in a clinical drug trial. Participants were self-administered a survey regarding WTP in a cardiovascular drug trial given to 1440 randomly selected patients from 13 Maryland outpatient cardiology and general medicine clinics. Patients reported their WTP, rated their perceived chances of experiencing health benefit and harm, and rated their distrust toward researchers. Of eligible participants, 70% responded, and 717 individuals were included: 36% African American and 64% white. African American participants possessed lower WTP than white participants (27% vs. 39%, p = 0.001) and had higher mean distrust scores than whites (p < 0.0001). African American participants more frequently reported that doctors would less fully explain research participation to them (24% vs. 13%, p < 0.001), use them as guinea...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Cardiology Discipline
Physician-Patient Relations
Medical Research Activity
Attitude to Health
Selection of Subjects
Cardiovascular Diseases
European Continental Ancestry Group
African American

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