Race/Ethnicity and the prevalence of thyrotoxicosis in young Americans

Thyroid : Official Journal of the American Thyroid Association
Donald S A McLeodSusan J Jordan

Abstract

Race/ethnicity may be a newly recognized risk factor for Graves' disease. The aim of this study was to examine the prevalence of thyrotoxicosis by race/ethnicity in Americans aged 12-49 years using three National Health and Nutritional Examination Surveys (NHANES). Data were analyzed from 17,939 participants in NHANES III (1988-1994), NHANES 1999-2002, and NHANES 2007-2010 with available thyroid function test results. Thyrotoxicosis was defined as a serum thyrotropin (TSH) of ≤0.1 mIU/L or subjects taking methimazole or propylthiouracil, and overt thyrotoxicosis was defined as high serum thyroxine and a serum TSH of ≤0.1 mIU/L. Logistic regression was performed accounting for the complex sampling design of NHANES, and the results from all three NHANES surveys were combined using a random-effects model. There were 75 study participants with point prevalent thyrotoxicosis, representing a pooled prevalence of 0.4% for Americans aged 12-49 years. Prevalent thyrotoxicosis was nearly three times more likely in non-Hispanic black subjects compared with non-Hispanic whites (OR=2.9 [CI 1.5-5.7]), while there was no difference between the prevalence of thyrotoxicosis in Mexican Americans compared to non-Hispanic whites (OR=1.2 [CI 0.6-2....Continue Reading

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Citations

Aug 4, 2015·Journal of Autoimmunity·Hanna J LeeYaron Tomer
Jul 1, 2015·Frontiers in Endocrinology·Enaam T ElhajMohamed F Lutfi
Nov 1, 2016·BMC Physiology·Enaam T ElhajMohamed F Lutfi
Jun 24, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ana L CreoSiobhan T Pittock
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Mar 29, 2019·Journal of Diabetes and Metabolic Disorders·Sayed Mahmoud Sajjadi-JaziBagher Larijani
Jul 4, 2020·Nature Reviews. Disease Primers·Terry F DaviesGeorge J Kahaly
Dec 12, 2018·Thyroid : Official Journal of the American Thyroid Association·Ana M RivasJoaquin Lado-Abeal
Aug 18, 2020·Respiratory Medicine Case Reports·Taiki HigakiAtsunori Nakao
Feb 29, 2020·Best Practice & Research. Clinical Endocrinology & Metabolism·Alessandro AntonelliPoupak Fallahi
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Nov 12, 2021·Archives of Endocrinology and Metabolism·Isabela M BenseñorPaulo A Lotufo

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