Race/ethnicity and the risk of childhood leukaemia: a case-control study in California

Journal of Epidemiology and Community Health
S OksuzyanL Kheifets

Abstract

We conducted a large registry-based study in California to investigate the association between race/ethnicity and childhood leukaemia focusing on two subtypes: acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML). We obtained information on 5788 cases and 5788 controls by linking California cancer and birth registries. We evaluated relative risk of childhood leukaemia by race and ethnicity of the child and their parents using conditional logistic regression, with adjustment for potential confounders. Compared with Whites, Black children had lower risk of ALL (OR=0.54, 95% CI 0.45 to 0.66) as well as children of Black/Asian parents (OR=0.31, 95% CI 0.10 to 0.94). Asian race was associated with increased risk of AML with OR=1.643, 95% CI 1.10 to 2.46 for Asian vs Whites; and OR=1.67, 95% CI 1.04 to 2.70 for Asian/Asian vs White/White. Hispanic ethnicity was associated with increased risk of ALL (OR=1.37, 95% CI 1.22 to 1.52). A gradient in risk of ALL was observed while comparing Hispanic children with both parents Hispanic, one parent Hispanic and non-Hispanic children (p Value for trend <0.0001). The highest risk of ALL was observed for children with a combination of Hispanic ethnicity and White race compared w...Continue Reading

References

Aug 1, 1992·American Journal of Epidemiology·G A McGradyC J Hogue
Jan 1, 1986·The American Journal of Pediatric Hematology/oncology·L G MacdougallR Bernstein
Jan 3, 1986·JAMA : the Journal of the American Medical Association·P H ShionoG G Rhoads
Jan 1, 1994·Epidemiologic Reviews·J A RossL L Robison
Jan 1, 1995·British Journal of Cancer·L J Kinlen
Apr 3, 1993·BMJ : British Medical Journal·L J Kinlen, C Stiller
Oct 1, 1996·British Medical Bulletin·C A Stiller, D M Parkin
Jul 1, 1997·Critical Care Clinics·C L Stewart, R Barnett
Oct 23, 1997·The New England Journal of Medicine·R J David, J W Collins
Nov 5, 1997·Annals of the New York Academy of Sciences·D Schuler, B Szende
Jul 31, 1998·Cancer Causes & Control : CCC·L J Kinlen
Apr 30, 1999·American Journal of Epidemiology·M L McBrideW Choi
Jul 2, 1999·International Journal of Cancer. Journal International Du Cancer·L M GreenK E Donnelly
Sep 16, 1999·British Journal of Cancer·H O Dickinson, L Parker
Feb 9, 2002·BMJ : British Medical Journal·Ruth Little
Mar 27, 2002·American Journal of Epidemiology·Peggy ReynoldsEric P Elkin
Apr 20, 2002·Epidemiology·Anssi AuvinenRiitta-Sisko Koskela
Oct 12, 2002·Medical and Pediatric Oncology·Dawn Elizabeth McNeilAlvin Mauer
Aug 14, 2003·American Journal of Epidemiology·Graham R LawUNKNOWN United Kingdom Childhood Cancer Study Investigators
Oct 17, 2003·American Journal of Epidemiology·Lisa Lyngsie HjalgrimEric A Engels
Jul 21, 2004·American Journal of Preventive Medicine·Richard C YangDeborah G Riordan
Jun 4, 2005·BMJ : British Medical Journal·Heather O Dickinson
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Kenneth C Schoendorf, Amy M Branum
Jul 22, 2006·World Journal of Urology·Sas Barmoshe, Alexandre R Zlotta
Aug 2, 2006·Paediatric and Perinatal Epidemiology·Danise PodvinMichelle Williams
Nov 17, 2006·Leukemia & Lymphoma·Matthew J MatasarAlfred I Neugut
Mar 17, 2007·Pediatric Blood & Cancer·Brenda R ClarkJohn R Wilkins
Apr 20, 2007·American Journal of Epidemiology·Elizabeth MilneNicholas de Klerk
Dec 12, 2007·Cancer·Scott C HowardRaul C Ribeiro
Dec 13, 2007·Cancer·Amy M Linabery, Julie A Ross
Jan 30, 2008·Journal of Clinical Epidemiology·Til StürmerJerry Avorn
Jan 29, 2009·International Journal of Cancer. Journal International Du Cancer·Robert W Caughey, Karin B Michels
Sep 10, 2013·Journal of the National Cancer Institute·Elixabet Lopez-LopezAfrica Garcia-Orad

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Citations

May 25, 2016·British Journal of Cancer·Catherine M CrespiLeeka Kheifets
Jun 7, 2017·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Leeka KheifetsXimena Vergara
Jun 12, 2019·International Journal of Environmental Research and Public Health·Erin C Peckham-GregoryPhilip J Lupo
Dec 14, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Valérie de HaasLing Zhang
Sep 14, 2017·Cancer Causes & Control : CCC·Leeka KheifetsXimena P Vergara
Sep 12, 2020·Thyroid : Official Journal of the American Thyroid Association·Nicole C DezielXiaomei Ma

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