Racial and Ethnic Disparities in the Pregnancies of Women With Systemic Lupus Erythematosus

Arthritis Care & Research
Megan Clowse, Chad Grotegut

Abstract

Both systemic lupus erythematosus (SLE; lupus) and pregnancy individually have significant racial disparities, with black women experiencing higher rates of complications, yet no large studies have focused on the impact of race/ethnicity on pregnancy outcomes among women with lupus. Using the Nationwide Inpatient Sample (NIS) for 2008-2010, pregnancy delivery discharges were identified and pregnancy outcomes were compared for women with lupus by maternal race/ethnicity. Adjusted odds ratios were used to compare pregnancy outcomes between black and white or Hispanic and white women with lupus. In this period, the NIS included 13,553 deliveries with lupus and 12,510,565 deliveries without lupus. Compared to white women with lupus, black and Hispanic women had higher rates of chronic hypertension, chronic renal failure, pneumonia, and acute renal failure. There was a high degree of pregnancy complication in all women with lupus, but especially in black and Hispanic women, with more than 40% cesarean-section delivery; preterm labor in 14.3% of white, 24.7% of black (odds ratio [OR] 1.97), and 20.6% of Hispanic (OR 1.56) deliveries; and preeclampsia and gestational hypertension in almost 20% of black and Hispanic pregnancies. After ...Continue Reading

References

May 23, 2002·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Feb 5, 2005·Arthritis and Rheumatism·Megan E B ClowseMichelle Petri
Aug 11, 2007·American Journal of Obstetrics and Gynecology·Haywood L BrownDaniel Howard
Aug 11, 2007·Maternal and Child Health Journal·Elena V KuklinaPolly A Marchbanks
May 6, 2008·American Journal of Obstetrics and Gynecology·Megan E B ClowseAndra H James
Aug 7, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Andrew SmythVesna D Garovic
Feb 22, 2013·Current Opinion in Obstetrics & Gynecology·Johanna P de GraafGouke J Bonsel
Apr 20, 2013·American Journal of Public Health·Richard J Shaw, Kate E Pickett
Jul 3, 2013·Obstetrics and Gynecology·Elizabeth A HowellNatalia Egorova
Apr 29, 2014·PloS One·Chad A GrotegutAndra H James
Jun 23, 2015·Annals of Internal Medicine·Jill P BuyonJane E Salmon
Jul 22, 2015·Current Opinion in Rheumatology·S Sam Lim, Cristina Drenkard

❮ Previous
Next ❯

Citations

Aug 9, 2016·Lupus·S Venuturupalli
May 19, 2017·Current Opinion in Rheumatology·Megan R W Barber, Ann E Clarke
Oct 1, 2016·Annual Review of Medicine·Lisa R Sammaritano
Apr 27, 2017·American Journal of Nephrology·Michelle M O'ShaughnessyWilliam F Pendergraft
Jan 25, 2020·Nature Reviews. Disease Primers·Hans-Joachim AndersChandra Mohan
Sep 15, 2021·Current Opinion in Rheumatology·Mehret Birru TalabiMegan E B Clowse
Dec 12, 2017·Best Practice & Research. Clinical Rheumatology·Rebecca Fischer-Betz, Christof Specker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.