Racial differences in myasthenia gravis in Alabama.

Muscle & Nerve
Shin Joong OhG C Claussen

Abstract

Demographic, clinical, and laboratory features were compared in 235 white and African-American (AA) patients with myasthenia gravis (MG) at the University of Alabama at Birmingham Neuromuscular Disease Clinic from May 2003 to January 2008. Seventy nine percent of patients were white. Acetylcholine receptor antibody was positive in 71% of white patients and in 59% of AA. In patients with seronegative generalized MG, the rate of positive muscle-specific tyrosine kinase antibody (MuSK-Ab) was significantly higher in AA than it was in whites (50% in AA vs. 17% in whites). Ocular MG was seronegative in 75% of AA patients. In AA, MG occurred earlier and more frequently in females, whereas, in whites, disease onset was later and more common in males. Another significant difference was a higher percentage of abnormality on repetitive nerve stimulation in AA. There was also a tendency for more severe forms of MG in AA. There are racial differences in MG between whites and AA in Alabama. These racial differences highlight the need to study biological factors in the pathogenesis of MG and to assess different approaches in diagnosis and treatment.

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Citations

Nov 23, 2012·Journal of Clinical Neuromuscular Disease·Shin J OhGwendolyn C Claussen
Mar 29, 2013·Autoimmunity Reviews·Amelia Evoli, Luca Padua
Nov 7, 2012·Wiener klinische Wochenschrift·Hakan CetinFritz Zimprich
Mar 29, 2011·Journal of the Neurological Sciences·Hiroyuki MuraiJun-ichi Kira
Jul 16, 2015·Autoimmune Diseases·Fawzi AbukhalilAaron McMurtray
Sep 10, 2013·Neuromuscular Disorders : NMD·Karen L SkjeiNancy L Kuntz
Sep 20, 2016·Muscle & Nerve·Marion Ingeborg BoldinghChantal Tallaksen
Sep 2, 2016·Journal of Child Neurology·Ha Neul LeeYoung-Mock Lee
Oct 5, 2017·Praxis·Yulia Valko, Konrad P Weber
Nov 30, 2018·Muscle & Nerve·Shin J OhMohammad Alsharabati
Jan 30, 2019·Acta Neurologica Scandinavica·Madhu NagappaArun B Taly
Dec 11, 2020·Chest·Deirdre Martinez-MeehanOlugbenga T Okusanya
Jan 14, 2020·Autoimmunity Reviews·Judith MerrheimNadine Dragin
Jun 3, 2021·Journal of Clinical Medicine·Laura DresserBetty Soliven

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