Racial differences in plasma high-density lipoproteins in patients receiving hemodialysis. A possible mechanism for accelerated atherosclerosis in white men

The New England Journal of Medicine
A GoldbergG Schonfeld

Abstract

Among 346 nondiabetic patients receiving long-term hemodialysis, cardiovascular mortality was higher in white than in black men (P less than 0.02) but was similar between black and white women, despite the higher incidence of nephrosclerosis in black men and women (59 and 58 per cent vs. 8 and 10 per cent, respectively; P less than 0.0001). There were significant racial differences in plasma lipid and apoprotein levels in a subset of 100 of these patients. The white men had higher levels of plasma triglyceride and lower levels of high-density-lipoprotein (HDL) cholesterol, apoprotein A-I, and apoprotein A-II than black men; concentrations of HDL, apoprotein A-I, and apoprotein A-II were also lower in white than in black women. The distribution of the HDL subfractions HDL2, HDL3, and HDL3D, as determined by zonal ultracentrifugation, was normal in black and abnormal in white men receiving hemodialysis. HDL2 concentrations were higher in black than in white men by both zonal analysis (P less than 0.05) and polyanionic precipitation of the HDL subfractions (P less than 0.01). The distributions and concentrations of HDL2 and HDL3L were similar in black and white women. Thus, there are marked racial differences in HDL in male patien...Continue Reading

References

Aug 1, 1977·Metabolism: Clinical and Experimental·J D BrunzellD J Sherrard
Feb 14, 1978·Biochemical and Biophysical Research Communications·H B BrewerT J Bronzert
Nov 1, 1979·Kidney International·S G RostandT E Andreoli
Dec 1, 1975·Preventive Medicine·H A TyrolerJ C Cassel
Jan 1, 1976·Analytical Biochemistry·A Bensadoun, D Weinstein
May 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H B BrewerK M John
May 1, 1974·The Journal of Clinical Investigation·G SchonfeldB Pfleger
Mar 28, 1974·The New England Journal of Medicine·A LindnerB H Scribner
Dec 1, 1971·Archives of Internal Medicine·J C Cassel
Oct 1, 1966·Circulation·J W GofmanR Tandy
Dec 1, 1980·European Journal of Clinical Investigation·H E Norbeck, L A Carlson
Mar 1, 1980·Progress in Cardiovascular Diseases·S ScharfM D Blaufox
Apr 1, 1982·Annals of Internal Medicine·T A HutchinsonB MacGibbon
Mar 1, 1982·The Medical Clinics of North America·R J Havel
May 27, 1982·The New England Journal of Medicine·S G RostandB A Pate
May 1, 1982·Kidney International·E A Friedman
Sep 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·R I Levy
Aug 5, 1982·The New England Journal of Medicine·P J NestelM H Tan
Dec 1, 1958·Journal of Chronic Diseases·S J CUTLER, F EDERER

❮ Previous
Next ❯

Citations

Dec 1, 1993·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U Querfeld
Jan 19, 1990·Klinische Wochenschrift·G FeussnerR Ziegler
Jan 1, 1994·Chemistry and Physics of Lipids·M D CressmanH F Hoff
Apr 15, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Ohta, I Matsuda
Feb 27, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·N RifaiR G Holly
Feb 1, 1995·International Journal of Cardiology·J J de LimaF Pileggi
Jun 22, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Ian F GodslandNishi Chaturvedi
Jul 21, 1999·Kidney International. Supplement·H KimuraM Arakawa
Oct 22, 1983·British Medical Journal·B Lewis
Mar 1, 1987·The American Journal of the Medical Sciences·A MendezS L Hsia
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·N G KutnerW D Hall
Jul 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P GoldwasserM M Avram
Oct 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D BroganE Flagg
Oct 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M M AvramN Mittman
Oct 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M A JosephsonA Dasgupta
Jun 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P O AttmanP Alaupovic
Jun 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K W MaL Raij
Jan 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J Rubiés-PratL Pira
Sep 1, 1987·Kidney International·P O AttmanA Gustafson
Jan 1, 1991·Kidney International·G Appel
Jul 1, 1985·Journal of the American Academy of Dermatology·F Parker
Sep 1, 1984·American Heart Journal·R P SterlingA W Fleming
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·H KimuraM Arakawa
May 1, 1985·Metabolism: Clinical and Experimental·B GonenG Schonfeld
May 1, 1990·Kidney International·M M FuhY D Chen
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J BleyerJ M Burkart
Apr 1, 1984·Kidney International·S G RostandE A Rutsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.