PMID: 15232365Jul 3, 2004Paper

Racial differences in response rates to consensus interferon in HCV infected patients naive to previous therapy

Journal of Clinical Gastroenterology
Paul J GaglioInfergen Study Group

Abstract

Despite a rapid evolution in the treatment of Hepatitis C (HCV), response to therapy among different racial and ethnic groups is poorly characterized. Three hundred and thirty HCV infected patients naive to previous therapy received induction therapy followed by every other day dosing with consensus interferon. Greater than 30% of treated patients were not white, allowing comparison of response among different races/ethnicities and genotypes. An overall sustained virologic response (SVR) was achieved in 24% of white, 12% of Hispanic, and 4% of AA patients (P = 0.003 white vs. non-white). 15% of white and 13% of Hispanic Genotype 1 patients achieved an SVR; 2% of AA patients achieved an SVR (P = 0.001 AA vs. non AA). Surprisingly, an SVR of 50% and 40% was achieved by AA and White Genotype 2 patients, compared with 10% in Hispanic patients (P = 0.001). Significant differences in response rates to induction therapy followed by every other day dosing with consensus Interferon was observed when comparing white to non-white patients, particularly when comparing response rates by genotype. These observations reinforce the requirement that prospective studies that enroll a significant percentage of non-whites are needed to adequately ...Continue Reading

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Citations

Jan 16, 2009·The New England Journal of Medicine·Maribel Rodriguez-TorresUNKNOWN Latino Study Group
Jun 19, 2009·Journal of Translational Medicine·Hideaki TaharaFrancesco M Marincola
Aug 27, 2009·Biologics : Targets & Therapy·Th Witthöft
Apr 21, 2010·Indian Journal of Medical Microbiology·J DavidP Abraham
Dec 14, 2006·Clinics in Liver Disease·Meera Ramamurthy, Andrew J Muir
Apr 16, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Victoria A SubletteKathryn Nicholson Perry
Sep 27, 2005·The American Journal of Gastroenterology·Ramsey C CheungUNKNOWN VA HCV-001 Study Group
May 14, 2009·The American Journal of Gastroenterology·Stanley YuJeffrey C Dunkelberg
Apr 15, 2010·The American Journal of Gastroenterology·Luis A BalartUNKNOWN LATINO study investigators
Jan 6, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul FeuerstadtJohn F Reinus
May 16, 2014·Journal of Clinical Gastroenterology·Steven L FlammGeoffrey M Dusheiko

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