Racial differences in sarcoidosis granuloma density.

Lung
Robert R BurkeBenjamin A Rybicki

Abstract

While sarcoidosis generally inflicts a greater morbidity on African-American compared with Caucasian patients, no studies have examined whether racial differences exist in the intensity of the histologic hallmark of sarcoidosis, noncaseating granulomas. The study was conducted as a retrospective case series in a tertiary referral center. The study included 187 patients with histopathologic confirmation of sarcoidosis by trans- and/or endobronchial biopsy between July 1991 and December 2001. Granuloma density was the average number of granulomas per biopsy piece on the slide with the most intense granulomatous inflammation at fourfold magnification. Overall, African-American patients had a twofold greater median granuloma density than Caucasians (p = 0.005). In a negative binomial multivariate model, radiographic pattern had the strongest association with granuloma density, with Scadding stage II and III patients having adjusted granuloma densities of 60% (p = 0.005) and 105% (p = 0.0001) higher than stage I patients. In the specific-tissue types, radiographic stage-adjusted granuloma densities in African-American patients were 49% greater in bronchial tissue (p = 0.03), but only a 27% greater in alveolar tissue (p = 0.51). A gr...Continue Reading

References

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Citations

Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wenrui HaoAvner Friedman
Nov 1, 2017·Annals of the American Thoracic Society·Alicia K GerkeLaura L Koth
Feb 9, 2011·The Tohoku Journal of Experimental Medicine·Hiroshi IshiiJun-ichi Kadota
Sep 16, 2021·Annals of the American Thoracic Society·David M PerlmanManeesh Bhargava
Nov 26, 2009·Current Opinion in Rheumatology
Jun 5, 2021·The European Respiratory Journal·Milica VukmirovicUNKNOWN GRADS Investigators

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