Abstract
Black men are disproportionately affected by both cardiovascular disease and prostate cancer. Epidemiologic evidence linking dyslipidemia, an established cardiovascular risk factor, and prostate cancer progression is mixed. As existing studies were conducted in predominantly non-black populations, research on black men is lacking. We identified 628 black and 1,020 non-black men who underwent radical prostatectomy and never used statins before surgery in the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Median follow-up was 2.9 years. The impact of preoperative hypercholesterolemia on risk of biochemical recurrence was examined using multivariable, race-stratified proportional hazards. In secondary analysis, we examined associations with low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, overall and among men with dyslipidemia. High cholesterol was associated with increased risk of recurrence in black [HR(per10 mg/dL) 1.06; 95% confidence interval (CI), 1.02-1.11] but not non-black men (HR(per10 mg/dL) 0.99; 95% CI, 0.95-1.03; P(interaction) = 0.011). Elevated triglycerides were associated with increased risk in both black and non-black men (HR(per10 mg/dL) 1.02; 95% CI, 1.00-1.03...Continue Reading
References
Jan 1, 1988·Journal of Clinical Epidemiology·P KnektM Hakama
Oct 24, 1998·American Journal of Epidemiology·P A MetcalfH A Tyroler
Mar 17, 2005·Circulation·George A MensahJanet B Croft
Jul 28, 2005·JAMA : the Journal of the American Medical Association·Stephen J FreedlandAlan W Partin
Dec 21, 2006·Journal of the National Cancer Institute·Elizabeth A PlatzEdward Giovannucci
Feb 2, 2008·Obesity·Joan F CarrollRoberto Cardarelli
May 12, 2009·Urology·Jennifer L Beebe-DimmerBenjamin A Rybicki
Sep 18, 2009·The Journal of Urology·Kelvin A MosesMuta M Issa
Nov 6, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jiyoung AhnDemetrius Albanes
Apr 28, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ruchika GuttStanley L Liauw
Oct 21, 2010·Metabolic Syndrome and Related Disorders·Susan Xiaoqin LinAlain Bertoni
Dec 1, 2010·Cancer Causes & Control : CCC·G David BattyMartin J Shipley
Apr 19, 2011·Journal of the National Cancer Institute·Wildon R FarwellJ Michael Gaziano
May 5, 2011·The Prostate·Ganna ChornokurNagi B Kumar
Nov 19, 2011·Prostate Cancer·Jennifer M PostBenjamin A Rybicki
Jan 21, 2012·BMC Cancer·Kashif ShafiqueDavid S Morrison
Jan 27, 2012·PloS One·Elahe A MostaghelR Bruce Montgomery
Jun 14, 2012·Cancer Causes & Control : CCC·Eric J JacobsSusan M Gapstur
Dec 12, 2012·European Urology·Emma H AllottStephen J Freedland
Apr 12, 2013·Cancer·Shellie D EllisJeannette T Bensen
Aug 13, 2013·PloS One·Gitanjali M SinghUNKNOWN Prospective Studies Collaboration (PSC)
Feb 13, 2014·European Journal of Epidemiology·Mathilde HisMathilde Touvier
Apr 29, 2014·Biochimica Et Biophysica Acta·Yuyang SunBrij B Singh
Aug 22, 2014·International Journal of General Medicine·Garth Graham
Aug 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Emma H AllottStephen J Freedland
Sep 11, 2014·Epidemiology·Christel HäggströmPär Stattin
Oct 12, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Emma H AllottStephen J Freedland
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
May 9, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Liu YuPengDu Chen
Citations
Oct 25, 2016·European Urology·Adriana C Vidal, Stephen J Freedland
Feb 27, 2018·Cancer Medicine·Tomi AkinyemijuSean F Altekruse
Sep 3, 2017·Cancer Causes & Control : CCC·Marshall K Tulloch-ReidMaria D Jackson
Nov 30, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jingjing Xie, Zhongyuan Xu
Sep 14, 2021·The Prostate·Vincent LethongsavarnGaëlle Fromont