Racial Disparities in Asthma-Related Health Outcomes in Children with Severe/Difficult-to-Treat Asthma

The Journal of Allergy and Clinical Immunology. in Practice
Theresa W GuilbertStanley J Szefler

Abstract

There are limited data that examine differences in asthma etiology between black and white children with severe or difficult-to-treat asthma. To describe demographic, clinical, and asthma-related outcomes in black and white children and examine whether differences in outcomes are explained by confounding factors in sequential multivariable models. Black (n = 86) and white (n = 262) children aged 6-11 years from The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens 3-year observational study were analyzed. Baseline demographics and clinical characteristics were described for both cohorts, and outcomes at month 12 were analyzed using statistical models, sequentially adjusting for potential confounders. Black children were more likely to be male (79.1% vs 66.4%; P < .05), obese (12.8% vs 1.5%; P < .001), and from a lower income stratum (USD43,400 vs 55,770; P < .001) than white children. Black children had higher geometric mean IgE levels (434.8 vs 136.8 IU/mL; P < .001), were more likely to have very poorly controlled asthma (72.1% vs 53.4%), use long-term systemic corticosteroids (30.2% vs 9.2%; P < .001), have poorer quality of life (5.5 vs 6.1; P < .001), and have an emergency department visit (27.4% ...Continue Reading

Citations

Jan 25, 2020·Pediatric Pulmonology·Kristie R Ross, Stanley J Szefler
Sep 7, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Imane Jroundi, Sze Man Tse
Mar 17, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Mark HewTunn Ren Tay
Jul 6, 2020·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Pasquale ComberiatiJoseph D Spahn
May 8, 2021·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Aubree C HoncoopRussell J McCulloh
May 30, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Monica J FedericoAnne L Fuhlbrigge
Jul 25, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Stanley J SzeflerGolda Hudes
Sep 5, 2021·Mayo Clinic Proceedings·Mamidipudi Thirumala KrishnaRuchi S Gupta
Oct 5, 2021·The Journal of Allergy and Clinical Immunology·Stephen VesperGurjit K Khurana Hershey
Oct 29, 2021·Expert Review of Respiratory Medicine·Sarah van den BergBerber Kapitein
Jan 26, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Michael SchatzRobert S Zeiger

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