Racial disparities in hematopoietic cell transplantation in the United States

Bone Marrow Transplantation
Navneet S MajhailEllen M Denzen

Abstract

Hematopoietic cell transplantation (HCT) is a highly specialized, expensive and resource-intense medical procedure that can be associated with racial disparities. We review the prevailing literature on racial disparities in HCT in the United States and describe areas for future research and interventions. We discuss the complexity of interpreting race as a biological and social determinant of disease in biomedical research, especially as it relates to HCT. In the United States, race is often a surrogate for socioeconomic, education and health insurance status. We also discuss some of the nuances to consider while reviewing the literature on racial disparities. Disparities by race exist in three areas related to HCT: donor availability, access to HCT and outcomes of HCT. African-Americans/Blacks have a lower likelihood of finding an unrelated donor. Race and ethnicity definitions are country-specific and reconciling race data can represent significant challenges to unrelated donor registries worldwide. African-Americans/Blacks do not have the same access to autologous and allogeneic HCT as Whites. Racial disparities in outcomes of HCT are more prevalent among allogeneic HCT than autologous HCT recipients. More research is requir...Continue Reading

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Related Concepts

Latinas
Transplantation, Homologous
Hemopoietic Stem Cell Transplant
Transplantation Conditioning
African Continental Ancestry Group
European Continental Ancestry Group
Healthcare Disparities
Biomedical Research
Donor Person
Literature

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