Racial disparities in heterotaxy syndrome

Birth Defects Research. Part A, Clinical and Molecular Teratology
Keila N LopezHeather A Dickerson

Abstract

Heterotaxy syndrome (HTX) is a constellation of defects including abnormal organ lateralization and often including congenital heart defects. HTX has widely divergent population-based estimates of prevalence, racial and ethnic predominance, and mortality in current literature. The objective of this study was to use a population-based registry to investigate potential racial and ethnic disparities in HTX. Using the Texas Birth Defects Registry, we described clinical features and mortality of HTX among infants delivered from 1999 to 2006. We calculated birth prevalence and crude prevalence (cPR) ratios for infant sex, maternal diabetes, and sociodemographic factors. A total of 353 HTX cases were identified from 2,993,604 births (prevalence ratio = 1.18 per 10,000 live births. HTX prevalence was approximately 70% higher among infants of Hispanic and non-Hispanic black mothers and 28% higher among female infants (cPR = 1.28; 95% confidence interval,1.04-1.59). There was a twofold higher female preponderance for infants of mothers who were non-Hispanic white or black. Mothers with diabetes were three times more likely to have a child with HTX compared with nondiabetics (cPR = 3.13; 95% confidence interval, 2.12-4.45). Among nondiabe...Continue Reading

References

Mar 1, 1984·Archives of Disease in Childhood·A R GatradG H Watson
Sep 15, 2000·Journal of the American College of Cardiology·T GilljamR M Freedom
Mar 21, 2001·Genetics in Medicine : Official Journal of the American College of Medical Genetics·A E LinL B Holmes
Oct 25, 2002·Teratology·Karen S Kuehl, Christopher Loffredo
Dec 19, 2003·American Journal of Human Genetics·Stephanie M WareJohn W Belmont
Apr 21, 2004·Current Opinion in Cardiology·John W BelmontStephanie M Ware
Mar 1, 2005·Diabetes Care·Dana DabeleaUNKNOWN Kaiser Permanente of Colorado GDM Screening Program
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Mona T Lydon-RochelleWilliam M Callaghan
Oct 22, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Craig A MasonPeter H Langlois
Oct 28, 2005·European Journal of Human Genetics : EJHG·Lirong ZhuStephanie M Ware
Oct 20, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Mark A CanfieldRussell S Kirby
Dec 13, 2006·Journal of the American College of Cardiology·Peter J BartzFrank Cetta
Jun 19, 2007·Obstetrics and Gynecology Clinics of North America·Kelly J Hunt, Kelly L Schuller
Feb 23, 2008·Cardiology in the Young·Jeffrey P JacobsMartin J Elliott
Jul 29, 2008·The Journal of Pediatrics·Mark D RellerAdolfo Correa
Aug 5, 2008·American Journal of Obstetrics and Gynecology·Adolfo CorreaE Albert Reece
Jan 17, 2009·Current Topics in Developmental Biology·Basudha Basu, Martina Brueckner
Feb 3, 2009·The Journal of Thoracic and Cardiovascular Surgery·H G LimF A Pigula
Feb 24, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Petros V AnagnostopoulosMichael F Teodori
Jul 15, 2009·Circulation·Nina ØyenMads Melbye
Sep 2, 2009·Archives of Disease in Childhood·C O'CallaghanE Moya
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin
May 11, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alain SerrafEmré Belli
Oct 5, 2010·The Journal of Thoracic and Cardiovascular Surgery·Matthew SwisherLinda Leatherbury
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Khalid A FakhroMartina Brueckner
Jul 7, 2011·Korean Circulation Journal·Soo-Jin Kim
Sep 23, 2011·Genome Biology·Muhammad TariqStephanie M Ware
Dec 17, 2011·Congenital Heart Disease·Lisa C A D'AlessandroVictoria Mok Siu
Jul 24, 2012·Journal of Clinical & Experimental Cardiology·Stephanie M Ware, John Lynn Jefferies
Sep 5, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lucina SuarezKatherine A Hendricks
Apr 1, 2011·World Journal for Pediatric & Congenital Heart Surgery·Jeffrey Phillip JacobsJames Anthony Quintessenza
Oct 15, 2013·Human Mutation·Jason CowanStephanie M Ware
Mar 1, 2014·Chest·Adam J ShapiroUNKNOWN Genetic Disorders of Mucociliary Clearance Consortium
Aug 8, 2014·American Journal of Medical Genetics. Part a·Angela E LinUNKNOWN National Birth Defects Prevention Study
Oct 10, 2014·Annals of Pediatric Cardiology·Shyam S Kothari

❮ Previous
Next ❯

Citations

Mar 6, 2016·Therapeutic Advances in Respiratory Disease·Rohit S LoombaRobert Anderson
Oct 17, 2019·Congenital Heart Disease·Christopher R BrodaHeather A Dickerson
Nov 16, 2016·Current Treatment Options in Cardiovascular Medicine·Karl Degenhardt, Jack Rychik
Jul 2, 2021·Pediatric Research·Renata H BenjaminA J Agopian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

American Journal of Diseases of Children
A GarzaJ Mulinare
Birth Defects Research. Part A, Clinical and Molecular Teratology
Wendy N NembhardJennifer L Kornosky
American Journal of Medical Genetics. Part a
A AgopianNational Birth Defects Prevention Study
Birth Defects Research. Part A, Clinical and Molecular Teratology
Peter H LangloisRuben K Cortez
© 2021 Meta ULC. All rights reserved