Abstract
Brain metastases (BM) cause symptoms that supportive medications can alleviate. We assessed whether racial disparities exist in supportive medication utilization after BM diagnosis. Medicare-enrolled patients linked with the Surveillance, Epidemiology, and End Results program (SEER) who had diagnoses of BM between 2007 and 2016 were identified. Fourteen supportive medication classes were studied: non-opioid analgesics, opioids, anti-emetics, anti-epileptics, headache-targeting medications, steroids, cognitive aids, antidepressants, anxiolytics, antidelirium/antipsychotic agents, muscle relaxants, psychostimulants, sleep aids, and appetite stimulants. Drug administration ≤30 days following BM diagnosis was compared by race using multivariable logistic regression. Among 17,957 patients, headache aids, antidepressants, and anxiolytics were prescribed less frequently to African Americans (odds ratio [95% CI] = 0.81 [0.73-0.90], P < 0.001; OR = 0.68 [0.57-0.80], P < 0.001; and OR = 0.68 [0.56-0.82], P < 0.001, respectively), Hispanics (OR = 0.83 [0.73-0.94], P = 0.004 OR = 0.78 [0.64-0.97], P = 0.02; and OR = 0.63 [0.49-0.81], P < 0.001, respectively), and Asians (OR = 0.81 [0.72-0.92], P = 0.001, OR = 0.67 [0.53-0.85], P = 0.001, a...Continue Reading
References
Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Mar 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A BezjakP Kirkbride
Mar 7, 2002·Critical Reviews in Oncology/hematology·Barbara Alicja Jereczek-FossaRoberto Orecchia
Sep 17, 2002·Archives of Internal Medicine·Limin X CleggBrenda K Edwards
Jan 29, 2005·Evaluation & the Health Professions·Christopher A FeddockTimothy S Caudill
Apr 2, 2005·American Journal of Clinical Oncology·Douglas KondziolkaL Dade Lunsford
Dec 13, 2005·Psychiatric Services : a Journal of the American Psychiatric Association·Sylvia Atdjian, William A Vega
Feb 16, 2006·Family Practice·Emmanuel ScheppersJoost Dekker
Mar 17, 2007·Health Services Research·Leah S KarlinerSunita Mutha
Nov 6, 2007·Clinical Oncology : a Journal of the Royal College of Radiologists·E ChowL Filipczak
Jan 7, 2009·Health Affairs·Beth A VirnigCathy J Bradley
Jun 30, 2009·Journal of Neuro-oncology·April F Eichler, Elizabeth B Lamont
Aug 20, 2009·JAMA : the Journal of the American Medical Association·Marie BakitasTim A Ahles
Dec 1, 2009·The Journal of Pain : Official Journal of the American Pain Society·Karen O AndersonRichard Payne
Jan 21, 2010·Psychological Medicine·M Pinquart, P R Duberstein
Feb 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Megan Dann FesinmeyerScott D Ramsey
Sep 8, 2010·The New England Journal of Medicine·Jennifer S TemelThomas J Lynch
Nov 11, 2010·Medical Care·Lisa C DiamondElizabeth A Jacobs
Dec 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janine Giese-DavisDavid Spiegel
Sep 23, 2011·Journal of Environmental Management·Giovanni LibralatoFrancesco Avezzù
Oct 1, 2011·Depression Research and Treatment·Zornitsa Kalibatseva, Frederick T L Leong
Oct 21, 2011·Current Oncology Reports·Lakshmi NayakPatrick Y Wen
Feb 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas J SmithJamie H Von Roenn
Oct 13, 2012·International Journal of Radiation Oncology, Biology, Physics·Lia M HalaszRinaa S Punglia
Jan 16, 2013·Journal of the American College of Surgeons·Adil H HaiderWaddah Al-Refaie
Aug 7, 2013·JAMA : the Journal of the American Medical Association·Jeffrey H SilberKevin R Fox
May 28, 2014·Cancer·Ayal A AizerPaul L Nguyen
Mar 26, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Gwen WyattGordan Srkalovic
Oct 16, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lu Chen, Christopher I Li
Nov 10, 2015·Journal of Pain and Symptom Management·Milagros D SilvaLisa C Diamond
Mar 30, 2016·International Journal of Radiation Oncology, Biology, Physics·Nitin OhriMadhur Garg
May 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Devon K CheckStacie B Dusetzina
Dec 31, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Betty R FerrellThomas J Smith
Jun 7, 2017·JAMA : the Journal of the American Medical Association·Ethan BaschDeborah Schrag
Oct 17, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Libby EllisScarlett Lin Gomez
Dec 11, 2017·Journal of the National Comprehensive Cancer Network : JNCCN·Benjamin H KannJames B Yu
Feb 2, 2018·BioMed Research International·Sanders ChangKavita V Dharmarajan
Aug 12, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Laura C PinheiroStacie Dusetzina
Jan 23, 2019·JAMA : the Journal of the American Medical Association·Fabrice DenisChristophe Letellier
Nov 11, 2019·Clinical & Experimental Metastasis·Mustafa S AschaJill S Barnholtz-Sloan
Jan 7, 2020·Neuro-oncology·Nayan LambaAyal A Aizer