Racial disparities in survival in malignant germ cell tumors of the ovary

Gynecologic Oncology
Emily HinchcliffJohn O Schorge

Abstract

To investigate racial disparities with respect to adjuvant treatment and survival in patients presenting with malignant ovarian germ cell tumors (OGCT). The National Cancer Database (NCDB) was used to identify women diagnosed with OGCT. Demographic data were abstracted, including stratification by race and histology. Standard univariate and multivariate analyses using logistic regression were performed to describe predictors of adjuvant treatment. Kaplan-Meier and Cox proportional hazards survival methods were used to evaluate racial differences in survival between African American (AA) and white (W) women. The study population included 2196 patients, with 1654 (75.3%) W and 328 (14.9%) AA women. Histologic distribution varied significantly by race (p<0.0001), but neither age nor stage at presentation showed racial differences (p=0.086 and p=0.209, respectively). AA received more chemotherapy than W (W: 54.6%, AA: 65.5%, p=0.008), but in multivariate analysis there was no statistically significant difference in any adjuvant treatment modality. Despite similar treatment, and independent of histology, survival varied significantly by race with 91% (CI 0.89-0.93) five year survival in W patients compared to 84% five year survival ...Continue Reading

References

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Citations

May 26, 2016·Gynecologic Oncology·Soledad JorgeJason D Wright
Dec 2, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Cecile Faure ConterAnne Lindsay Frazier
Mar 7, 2018·The Journal of Surgical Research·Laura L StafmanElizabeth A Beierle
Aug 17, 2021·Gynecologic Oncology·Meerim ParkYoung-Joo Won

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