Racial disparities in tumor features and outcomes of patients with squamous cell carcinoma of the tonsil

The Laryngoscope
Ashley AlbertSrinivasan Vijayakumar

Abstract

To identify differences in 3-year overall survival (OS) and disease-free survival (DFS) based on race in patients with tonsillar squamous cell carcinoma. We retrospectively analyzed 80 patients with squamous cell carcinoma of the tonsil treated between 2006 and 2015. Overall survival and DFS curves comparing white and black patients were generated using the Kaplan-Meier method. Cox regression was used to determine covariables associated with OS and DFS. Forty-one percent of the patients in this cohort were black and 59% were white. Three-year OS for black patients was 45.5% versus 88.1% for white patients (P = 0.003). Three-year DFS for black patients was 41.1% versus 66.6% in white patients (P = 0.001). Black race (hazard ratio [HR] 4.81, 95% confidence interval [CI] 1.48-15.6, P = 0.009) and lack of insurance (HR 9.50, 95% CI 2.92-13.0, P < 0.009) were independently associated with worse OS on multivariable analysis. Black patients were more likely to have high-risk tumor features. Black patients with stage IV disease (American Joint Committee on Cancer, 7th edition) had decreased OS as compared to white patients, 41.4% versus 82.1% (P = 0.005). There was a trend toward worse OS in human papillomavirus (HPV)-negative black pa...Continue Reading

References

Jul 31, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G G GrabenbauerL Distel
Sep 17, 1998·Archives of Otolaryngology--head & Neck Surgery·H T HoffmanH R Menck
Jun 7, 2000·Tobacco Control·C Anderson, D M Burns
Sep 25, 2001·International Journal of Radiation Oncology, Biology, Physics·B O'SullivanB Cummings
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Peter B BachColin B Begg
Apr 29, 2003·Cancer Metastasis Reviews·Vickie L ShaversWilliam W Davis
Apr 6, 2004·CA: a Cancer Journal for Clinicians·Elizabeth WardMichael Thun
Jul 11, 2006·The Laryngoscope·Christine G Gourin, Robert H Podolsky
May 3, 2007·The Laryngoscope·Anthony C Nichols, Neil Bhattacharyya
Nov 1, 2007·Head & Neck·W Jarrard GoodwinJennifer J Hu
Dec 22, 2007·CA: a Cancer Journal for Clinicians·Elizabeth WardAhmedin Jemal
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
May 23, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Leonor Varela-LemaCamille C Ragin
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Jun 22, 2010·The Laryngoscope·Paul M WeinbergerWilliam S Dynan
Oct 23, 2010·Head & Neck·Camille C RaginEmanuela Taioli
Oct 5, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anil K ChaturvediMaura L Gillison
Jan 17, 2012·Head & Neck·Matthew E SpectorUNKNOWN University of Michigan Head Neck Specialized Program of Research Excellence (SPORE) Program
Jun 8, 2012·Cancer Causes & Control : CCC·Jeanette A StingoneAndrew F Olshan
Mar 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria J WorshamGeorge Divine
Jun 19, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Azeem S KakaTheodoros N Teknos
Jul 19, 2013·Radiation Oncology Journal·Tae Ryool Koo, Hong-Gyun Wu
May 16, 2015·Cancer Epidemiology·Darien J WeatherspoonIsabel Garcia
Nov 4, 2016·International Journal of Cancer. Journal International Du Cancer·Erik LiederbachMihir K Bhayani
Dec 28, 2016·Carcinogenesis·Camille RaginEmanuela Taioli
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 23, 2017·Oral Oncology·Uchechukwu C Megwalu, Yifei Ma
Feb 10, 2017·Anticancer Research·Uchechukwu C Megwalu, Yifei Ma
Dec 9, 2017·Journal of the American College of Radiology : JACR·Rahul P BhandariSrinivasan Vijayakumar
Dec 12, 2018·Oral Oncology·Juliana de Brito RangelJorge Francisco da Cunha Pinto

❮ Previous
Next ❯

Citations

Jun 5, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Melanie TownsendRyan S Jackson
Sep 22, 2020·Cancer Control : Journal of the Moffitt Cancer Center·Chengzhuo LiJun Lyu
Sep 29, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Jessica D McDermottSana D Karam

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.