Racial variations in the performance of prostate specific antigen and prostate specific antigen density in the era of extended prostate biopsy schemes

The Journal of Urology
Christopher S ElliottJ C Presti

Abstract

The incidence of prostate cancer is known to vary as a function of race. To date few studies have evaluated the performance of the prostate specific antigen test and its indexes in unique racial populations. We examined the performance of prostate specific antigen, prostate specific antigen density and transition zone density in racial groups undergoing an extended prostate biopsy scheme. A retrospective review was performed of prospectively collected data on 1,115 white, 288 black and 161 Asian/Pacific Islander men referred for prostate needle biopsy. All participants had not undergone previous biopsy. ROC curves stratified by race were ascertained for prostate specific antigen, prostate specific antigen density and transition zone density for detecting cancer and high grade cancer (Gleason 3 + 4 or greater). Across all races prostate specific antigen density outperformed prostate specific antigen for detecting any prostate cancer and high grade cancer. Prostate specific antigen and prostate specific antigen density performed best for diagnosing high grade cancer and diagnosing cancer in men with an abnormal digital rectal examination. When comparing differing races, prostate specific antigen density performed the best in Asia...Continue Reading

References

Oct 25, 1995·JAMA : the Journal of the American Medical Association·J W MoulD G McLeod
Aug 1, 1996·The New England Journal of Medicine·T O MorganJ W Moul
Feb 26, 2003·Clinical Chemistry·Carsten StephanKlaus Jung
Feb 11, 2004·Archives of Internal Medicine·G Divakara MurthyDonald Pasquale
Sep 29, 2004·Archives of Internal Medicine·Timothy GilliganJerry Avorn
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Ian M ThompsonCharles A Coltman
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Mar 30, 2007·CA: a Cancer Journal for Clinicians·Robert A SmithHarmon J Eyre

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Citations

Feb 13, 2009·BJU International·John M FitzpatrickStephane Oudard
Oct 6, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Gouhei TanakaKazuyuki Aihara
Jan 16, 2010·Revista do Colégio Brasileiro de Cirurgiões·Aissar Eduardo NassifHelio Jorge Pozzobon

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