Racial/ethnic disparities in de novo metastases sites and survival outcomes for patients with primary breast, colorectal, and prostate cancer

Cancer Medicine
Tomi AkinyemijuSean F Altekruse

Abstract

Racial disparities in cancer mortality still exist despite improvements in treatment strategies leading to improved survival for many cancer types. In this study, we described race/ethnic differences in patterns of de novo metastasis and evaluated the association between site of de novo metastasis and breast, prostate, and colorectal cancer mortality. Data were obtained from the Surveillance Epidemiology and Ends Results (SEER) database from 2010 to 2013 and included 520,147 patients ages ≥40 years with primary diagnosis of breast, colorectal, or prostate cancer. Site and frequency of de novo metastases to four sites (bone, brain, liver, and lung) were compared by race/ethnicity using descriptive statistics, and survival differences examined using extended Cox regression models in SAS 9.4. Overall, non-Hispanic (NH) Blacks (11%) were more likely to present with de novo metastasis compared with NH-Whites (9%) or Hispanics (10%). Among patients with breast cancer, NH-Blacks were more likely to have metastasis to the bone, (OR: 1.25, 95% CI: 1.15-1.37), brain (OR: 2.26, 95% CI: 1.57-3.25), or liver (OR: 1.62, 95% CI: 1.35-1.93), while Hispanics were less likely to have metastasis to the liver (OR: 0.76, 95% CI: 0.60-0.97) compared...Continue Reading

References

Jan 1, 1995·Critical Reviews in Oncology/hematology·M Koutsilieris
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Jun 3, 2000·Human Pathology·L BubendorfM J Mihatsch
Mar 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jyoti MehrotraSaraswati Sukumar
Jan 5, 2005·The Journal of Clinical Investigation·Andy J MinnJoan Massagué
Jan 6, 2010·Annals of Surgical Oncology·Keith A DookeranSarah Gehlert
Feb 12, 2010·American Journal of Public Health·Nancy KriegerPamela D Waterman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Nov 29, 2011·Health & Place·Neng WanJohn P Tiefenbacher
Jun 1, 2012·Journal of Gastroenterology and Hepatology·Takafumi TamuraNobuhiro Ohkohchi
Jan 23, 2013·American Journal of Men's Health·Samuel AntwiSteve T Fleming
Aug 7, 2013·JAMA : the Journal of the American Medical Association·Jeffrey H SilberKevin R Fox
Nov 18, 2014·Oncotarget·Jan BudcziesAlbrecht Stenzinger
May 3, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Ramzi AmriDavid L Berger
Jul 15, 2015·Journal of breast cancer·Malcolm D MattesEvangelia Katsoulakis
Aug 2, 2015·Cancer Epidemiology·Tomi F AkinyemijuHenna Budhwani
Oct 28, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda ValeriBrent A Coull
Jan 27, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Emma H AllottStephen J Freedland
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Aug 2, 2016·Clinical Lung Cancer·Jordan A TorokJoseph K Salama
Aug 10, 2016·The British Journal of Surgery·H G SmithA J Hayes
Sep 13, 2016·Vaccines·Serena Zilio, Paolo Serafini

❮ Previous
Next ❯

Citations

Jun 18, 2019·Cancer·Siún M WalshMary L Gemignani
Jul 3, 2018·Oncotarget·Ha Son NguyenMartin M Mortazavi
Nov 18, 2018·Cancers·Bernadette NeveIsabelle Van Seuningen
Jul 27, 2020·Journal of Cancer Research and Clinical Oncology·Jairo RamosDeodutta Roy
Nov 30, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jingjing Xie, Zhongyuan Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Disparities

Cancer disparities refers to differences in cancer outcomes (e.g., number of cancer cases, related health complications) across population groups.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.