Racial/ethnic variations in non-steroidal anti-inflammatory drug (NSAID) use among patients with osteoarthritis

Pharmacoepidemiology and Drug Safety
Kelli L DominickRonnie D Horner

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed drugs for the treatment of osteoarthritis (OA). While there are documented racial differences in the use of opioid analgesics, little is known about racial differences in the use of NSAIDs. This was a retrospective cohort study among a national sample of 6038 veterans with OA. Patients were new NSAID users, followed for approximately 6 months. Primary outcomes included: type of NSAID prescribed (COX-2 selective or preferentially COX-2 selective NSAIDs vs other NSAIDs), days' supply of initial prescription and time to discontinuation of the index NSAID. In an analysis adjusted for demographic and gastrointestinal (GI) bleeding risk factors (age, sex, geographic region, history of GI bleeding, comorbid illnesses, use of anti-coagulants and glucocorticoids), Hispanics were less likely than whites to be prescribed an NSAID with some degree of COX-2 selectivity (odds ratio (OR): 0.47, p < 0.01). The days' supply of the initial prescription was lower for both blacks and Hispanics compared to whites (mean: 38, 31 and 43 days respectively, p < 0.01). In an analysis adjusted for demographics, GI bleeding risk factors and type of NSAID prescribed, blacks disc...Continue Reading

Citations

Feb 28, 2008·Journal of General Internal Medicine·Somnath SahaSaid Ibrahim
Dec 26, 2006·Journal of Palliative Medicine·Alexie Cintron, R Sean Morrison
Feb 22, 2008·Journal of Aging and Health·Steven M AlbertMyrna Silverman
Jan 14, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Salimah H MeghaniRollin M Gallagher
Mar 12, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Salimah H Meghani
Oct 14, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Zachary A MarcumUNKNOWN Health, Aging and Body Composition Study
Jul 9, 2013·Annals of Epidemiology·Aletta DijkstraFanny Janssen
Dec 1, 2009·The Journal of Pain : Official Journal of the American Pain Society·Karen O AndersonRichard Payne
Jul 15, 2009·The Journal of Pain : Official Journal of the American Pain Society·Lisa C CampbellFrancis J Keefe
Oct 26, 2006·The American Journal of Geriatric Pharmacotherapy·Theresa I Shireman, Sally K Rigler
Jul 25, 2006·The American Journal of Geriatric Pharmacotherapy·Gerda G Fillenbaum, Joseph T Hanlon
Nov 23, 2007·Journal of Women & Aging·Karen A RobertoA Kate Holland
Apr 11, 2014·Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society·Robert Lavin, Juyoung Park
Jan 17, 2013·The Journal of International Medical Research·M N EssexP Bhadra Brown
Jun 16, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Andrea K NewmanBeverly E Thorn
Jul 28, 2017·Archives of Orthopaedic and Trauma Surgery·Adam DriesmanKenneth A Egol
Sep 21, 2018·Pharmacoepidemiology and Drug Safety·Edward Chia-Cheng LaiSoko Setoguchi
Jul 20, 2021·The Journal of Pain : Official Journal of the American Pain Society·Monika PatelKimberly T Sibille

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