Racioethnic differences in the biomechanical response of the lamina cribrosa

Acta Biomaterialia
Reza BehkamJonathan P Vande Geest

Abstract

Glaucoma is the second leading cause of irreversible blindness in the world with a higher prevalence in those of African Descent (AD) and Hispanic Ethnicity (HE) than in those of European Descent (ED). The objective of this study was to investigate the pressure dependent biomechanical response of the lamina cribrosa (LC) in normal human donor tissues from these racioethnic backgrounds. Pressure inflation tests were performed on 24 human LCs (n = 9 AD, n = 6 ED, and n = 9 HE) capturing the second harmonic generation (SHG) signal of collagen at 5, 15, 30, and 45 mmHg from an anterior view. A non-rigid image registration technique was utilized to determine the 3D displacement field in each LC from which 3D Green strains were calculated. The peak shear strain in the superior quadrant of the LC in those of ED was significantly higher than in those of AD and HE (p-value = 0.005 & 0.034, respectively) where ED = 0.017 [IQR = 0.012-0.027], AD = 0.0002 [IQR = -0.001-0.007], HE = 0.0016 [IQR = -0.002-0.012]). There were also significant differences in the regional strain heterogeneity in those of AD and HE that were absent in those of ED. This work represents, to our knowledge, the first ex-vivo study identifying significant differences ...Continue Reading

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Citations

Apr 29, 2020·Investigative Ophthalmology & Visual Science·Dan MidgettThao D Nguyen
Aug 29, 2020·Translational Vision Science & Technology·Jr-Jiun LiouJonathan P Vande Geest
Nov 10, 2020·Investigative Ophthalmology & Visual Science·Andrew P VoorheesIan A Sigal
Mar 18, 2021·The Application of Clinical Genetics·Altaf A Kondkar

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