RACK-1, a multifaceted regulator is required for C. elegans innate immunity against S. flexneri M9OT infection

Developmental and Comparative Immunology
Shanmugam MarudhupandiyanKrishnaswamy Balamurugan

Abstract

The nematode C. elegans has the ability to clear off bacterial colonization in the intestine using pathogen specific innate immune response. Here, we show that C. elegans RACK-1 has been vital in determining the survival of worms under specific pathogenic infection. Among various pathogens tested, S. flexneri M9OT (SF) exhibited highest pathogenicity by killing rack-1 mutant worm-VC3013 earlier when compared to WT. The expression level of rack-1 mRNA was found to be decreased and it further indicated that the host translational event appeared to be affected during SF infection. Hence, inhibition of translational machinery was the foremost reason for the early mortality in C. elegans. Apparently, variation in the expression of RACK-1 affects the activation of p38 and JNK-MAPK pathway which consequently triggered expression of nlp-29 and longevity, respectively. The study unveils novel defense mechanisms exist for C. elegans in facilitating enhanced immunity by RACK-1 against SF infection.

Citations

Jun 20, 2019·Frontiers in Cellular and Infection Microbiology·Dilawar Ahmad Mir, Krishnaswamy Balamurugan
Nov 18, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sethuraman SathyaKasi Pandima Devi
May 23, 2021·Microbial Pathogenesis·Murugesan PooranachithraKrishnaswamy Balamurugan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Médecine sciences : M/S
Katja Ziegler, Nathalie Pujol
Proceedings of the National Academy of Sciences of the United States of America
Cheng-Gang ZouKe-Qin Zhang
© 2022 Meta ULC. All rights reserved