Racotumomab for treating lung cancer and pediatric refractory malignancies

Expert Opinion on Biological Therapy
Mariano R GabriDaniel F Alonso

Abstract

Racotumomab (originally known as 1E10 mAb) is an anti-idiotype murine IgG1 directed to membrane glycoconjugates expressed in aggressive solid tumors. It was developed as a mirror image of the idiotype of another antibody against N-glycolyl-containing molecules, such as the NeuGcGM3 ganglioside. After a successful phase II/III study, racotumomab formulated in alum was conditionally approved in Latin American countries as maintenance therapy for advanced non-small cell lung cancer. This review analyzes the biology of the target antigen, summarizes preclinical studies and discusses clinical trials in adults and the pediatric experience with racotumomab. Proper patient selection and combination with chemotherapy, radiotherapy or checkpoint inhibitors appear to be critical issues to maximize the effects of racotumomab vaccination in lung cancer. In a recent phase I clinical trial in children with relapsed or resistant neuroectodermal malignancies, racotumomab was well tolerated and immunogenic, and its evaluation as immunotherapy for high-risk neuroblastoma is warranted.

References

Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S Hakomori
Jun 26, 2001·Glycoconjugate Journal·R Schauer
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mauro AlfonsoAna María Vázquez
May 24, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alain DíazAna María Vázquez
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thorsten SimonFrank Berthold
Nov 24, 2004·The Journal of Biological Chemistry·Muriel BardorAjit Varki
Dec 14, 2007·Cancer Biology & Therapy·Saily AlfonsoAmparo E Macias
Jan 2, 2008·Biochimica Et Biophysica Acta·Samir Kumar Patra
May 14, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Alejandra M ScursoniMaría Teresa G de Dávila
Sep 1, 2009·Journal of Experimental & Clinical Cancer Research : CR·Marina Isla LarrainMaría Virginia Croce
Jan 22, 2010·Expert Opinion on Biological Therapy·Mayrel LabradaLuis E Fernández
Oct 1, 2010·The New England Journal of Medicine·Alice L YuUNKNOWN Children's Oncology Group
Nov 5, 2010·Clinical & Developmental Immunology·Luis E FernandezDaniel F Alonso
May 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine K MatthayAlice L Yu
Dec 21, 2012·Pediatric Blood & Cancer·Julie R ParkUNKNOWN COG Neuroblastoma Committee
May 25, 2013·Nature Reviews. Cancer·Nai-Kong V Cheung, Michael A Dyer
May 30, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Johan VansteenkisteVincent G Brichard
Sep 3, 2013·Expert Opinion on Biological Therapy·Nicholas VeomettDavid A Scheinberg
Feb 13, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Brian H KushnerNai-Kong V Cheung
May 3, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sailyn AlfonsoAmparo E Macías
Jun 1, 2014·Expert Opinion on Biological Therapy·Anish Thomas, Marko Jakopovic
Aug 26, 2014·Expert Review of Anticancer Therapy·Christian RolfoLuis Raez
Nov 19, 2014·Acta Ophthalmologica·Ana Vanesa TorbidoniMaría Teresa G de Dávila
Nov 26, 2014·Expert Review of Vaccines·Ana María Hernández, Ana María Vázquez
Mar 27, 2015·Pediatric Blood & Cancer·Nehal S ParikhUNKNOWN International Society of Pediatric Oncology
Jul 15, 2015·Pediatric Blood & Cancer·Walter CacciavillanoGuillermo L Chantada
Aug 19, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GiacconeH Fakhrai

❮ Previous
Next ❯

Citations

Mar 16, 2017·Chembiochem : a European Journal of Chemical Biology·Sophie Groux-DegrootePhilippe Delannoy
Jun 3, 2020·Antibodies·Aliya K StanovaYehuda Shoenfeld
Nov 20, 2018·Frontiers in Immunology·Matthew J BuettnerKevin J Yarema
Jul 10, 2021·Critical Reviews in Oncology/hematology·Jasmine KaurMing Q Wei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.