Ractopamine residue in meat might protect people from Parkinson disease.

Medical Hypotheses
Frank S Fan

Abstract

There is still no curative treatment for the exasperating Parkinson disease, the second most common neurodegenerative disorder. Intracytoplasmic Lewy body composing of phosphorylated α-synuclein in dopaminergic neuronal cells has been recognized as the characteristic pathologic change and believed to be the cause of neuronal cell loss in Parkinson disease. Recently, β-adrenoreceptor antagonist was found to be correlated with an increasing incidence of Parkinson disease and β-adrenoreceptor agonist, capable of inhibiting gene expression of α-synuclein, was associated with a reduced incidence of it. Therefore, a hypothesis is raised that ractopamine, a β-adrenoreceptor agonist used as feed additive for increasing leanness of finishing cattle and swine, might provide protective effects for Parkinson disease and lower its incidence in the population consuming meat containing ractopamine residue.

References

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Citations

Aug 3, 2021·Frontiers in Cell and Developmental Biology·Longping YaoGuohui Lu

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Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

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