RAD51 135G>C polymorphism and breast cancer risk: a meta-analysis

Breast Cancer Research and Treatment
Guo-Wu ZhouQiang Li

Abstract

Mutations in RAD51 gene are believed to be associated with elevated breast cancer risk. However, several case-control studies focusing on the association between RAD51 135G>C and breast cancer risk failed to achieve consensus. To clarify the effect of RAD51 135G>C polymorphism on breast cancer, a meta-analysis was performed. By searching PubMed and EMBASE, a total of 14 case-control studies, containing 12,183 cases and 10,183 controls, were included. The strength of association between RAD51 135G>C polymorphism and breast cancer risk was assessed by odds ratio (OR) with the corresponding 95% confidence interval (95% CI). When all the eligible studies were pooled into the meta-analysis, an elevated cancer risk was revealed in additive model (OR, 1.34; 95% CI, 1.01-1.78; P = 0.044) and recessive model (OR, 1.37; 95% CI, 1.03-1.82; P = 0.032). In subgroup analyses by ethnicity, BRCA1/2 mutation status, and family history, a significant association was found only among BRCA2 mutation carriers (additive model: OR, 4.92; 95% CI, 1.11-21.83; P = 0.036; recessive model: OR, 4.88; 95% CI, 1.10-21.67; P = 0.037). Sensitivity analysis did not perturb the results. In conclusion, this meta-analysis suggests that RAD51 variant 135C homozygot...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 11, 1998·Trends in Biochemical Sciences·P Baumann, S C West
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·E Levy-LahadR Gershoni-Baruch
Jan 29, 2002·Statistics in Medicine·Jesse A BerlinUNKNOWN Anti-Lymphocyte Antibody Induction Therapy Study Group
May 25, 2002·Human Molecular Genetics·Bettina KuschelAlison Dunning
Jun 6, 2003·The New England Journal of Medicine·Richard Wooster, Barbara L Weber
Feb 23, 2005·Cancer Letters·John Thacker
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Penelope M WebbAmanda B Spurdle
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kyoung-Mu LeeDaehee Kang
Nov 2, 2005·Breast Cancer Research and Treatment·Tomasz SliwinskiJanusz Blasiak
Apr 21, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Inabr GalEitan Friedman
May 23, 2006·The Breast : Official Journal of the European Society of Mastology·Tsai-Wang ChangWenya Huang
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Anna JakubowskaUte Hamann
Sep 25, 2007·Cancer Genetics and Cytogenetics·Lilian JaraPatricio González-Hormazábal
Nov 14, 2007·American Journal of Human Genetics·Antonis C AntoniouUNKNOWN Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA)
Apr 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jennifer BrooksIsaac Wirgin
Dec 17, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Anna JakubowskaUNKNOWN IHCC-Breast Cancer Study Group
May 12, 2009·Experimental and Molecular Pathology·Renata KrupaJanusz Blasiak
Jan 8, 2010·Breast Cancer Research and Treatment·Lilian JaraPatricio González-Hormazábal
Apr 2, 2010·Molecular Biology Reports·Elif AkisikNejat Dalay

❮ Previous
Next ❯

Citations

Nov 27, 2010·Breast Cancer Research and Treatment·Pei-Hua LuGuo-Qing Tao
Aug 23, 2012·Breast Cancer Research and Treatment·Khyber Saify, Mostafa Saadat
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mahmood Akhtar KayaniIshrat Mahjabeen
Oct 31, 2014·Journal of Cancer Research and Clinical Oncology·K Söderlund LeiflerM Stenmark Askmalm
Nov 11, 2014·Journal of Surgical Oncology·Thereasa A RichBanu Arun
Jun 13, 2018·Journal of Cancer Research and Therapeutics·Nasrin YazdanpanahiSara Kamali
Feb 4, 2019·Pathology Oncology Research : POR·Beata SmolarzLuiza Wójcik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.