RAD51-independent break-induced replication to repair a broken chromosome depends on a distant enhancer site

Genes & Development
A MalkovaJ E Haber

Abstract

Without the RAD51 strand exchange protein, Saccharomyces cerevisiae cannot repair a double-strand break (DSB) by gene conversion. However, cells can repair DSBs by recombination-dependent, break-induced replication (BIR). RAD51-independent BIR is initiated more than 13 kb from the DSB. Repair depends on a 200-bp sequence adjacent to ARS310, located approximately 34 kb centromere-proximal to the DSB, but does not depend on the origin activity of ARS310. We conclude that the ability of a recombination-induced replication fork to copy > 130 kb to the end of the chromosome depends on a special site that enhances assembly of a processive repair replication fork.

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M S Esposito
Mar 25, 1992·Nucleic Acids Research·D GietzR H Schiestl
Jan 1, 1987·Methods in Enzymology·J D BoekeG R Fink
Jan 1, 1984·Cold Spring Harbor Symposia on Quantitative Biology·R Kostriken, F Heffron
Jan 1, 1993·Cold Spring Harbor Symposia on Quantitative Biology·C S NewlonJ F Theis
May 31, 1996·Cell·T Kogoma
Jul 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·A MalkovaJ E Haber
Apr 7, 1998·Molecular and Cellular Biology·F PâquesJ E Haber
Jun 5, 1999·Microbiology and Molecular Biology Reviews : MMBR·F Pâques, J E Haber
Jul 3, 1999·Trends in Biochemical Sciences·J E Haber
Dec 10, 1999·Microbiology and Molecular Biology Reviews : MMBR·A Kuzminov
Apr 8, 2000·Trends in Biochemical Sciences·S C Kowalczykowski
Apr 8, 2000·Trends in Biochemical Sciences·K N Kreuzer
Apr 8, 2000·Trends in Biochemical Sciences·B Michel
Nov 30, 2000·Molecular and Cellular Biology·L E Kang, L S Symington
Dec 2, 2000·Nature Genetics·M A DunhamR R Reddel
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A MalkovaJ E Haber

❮ Previous
Next ❯

Citations

Jan 28, 2003·DNA Repair·Kyungjae Myung, Richard D Kolodner
Dec 6, 2011·Nature Structural & Molecular Biology·Yoshitami HashimotoVincenzo Costanzo
Nov 2, 2001·The EMBO Journal·N GrandinM Charbonneau
Feb 1, 2011·Journal of Molecular Cell Biology·Chris AllenJac A Nickoloff
Aug 6, 2004·Applied and Environmental Microbiology·Manuel RamírezJosé E Rebollo
Mar 3, 2004·Molecular and Cellular Biology·Allison P Davis, Lorraine S Symington
Nov 29, 2002·Microbiology and Molecular Biology Reviews : MMBR·Lorraine S Symington
Jun 8, 2006·Annual Review of Biochemistry·Michael J McEachern, James E Haber
Jun 10, 2010·Future Oncology·Yiyi YanRandy Legerski
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·E KrausJ E Haber
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·John R Vance, Thomas E Wilson
Jul 27, 2010·Environmental and Molecular Mutagenesis·John M Hinz
Jul 27, 2010·Environmental and Molecular Mutagenesis·Randy J Legerski
Nov 28, 2002·Molecular Cell·Marie Frank-Vaillant, Stéphane Marcand
Feb 19, 2002·Oncogene·Victoria Lundblad
Nov 5, 2002·Nature Reviews. Molecular Cell Biology·Peter McGlynn, Robert G Lloyd
Jan 31, 2017·Genes·Bazilė Ravoitytė, Ralf Erik Wellinger
Apr 22, 2017·Critical Reviews in Biochemistry and Molecular Biology·Cynthia J Sakofsky, Anna Malkova
Jul 14, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexander J NeilSergei M Mirkin
Oct 23, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John P Murnane, Laure Sabatier
Oct 13, 2016·Annual Review of Genetics·James E Haber
Jul 19, 2002·The Journal of Biological Chemistry·Silvia AyoraJuan C Alonso
Jun 25, 2015·Microbiology Spectrum·Richard McCullochJames P J Hall
Apr 2, 2021·Annual Review of Biochemistry·Z W KocklerA Malkova
Jul 4, 2006·Cell·James E Haber, Michelle Debatisse
Oct 31, 2017·ACS Chemical Biology·Danielle N Gallagher, James E Haber
Sep 2, 2021·The Journal of Physical Chemistry. B·Ishani MukherjeePradipta Purkayastha

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.