Rad52 has a role in the repair of sodium selenite-induced DNA damage in Saccharomyces cerevisiae

Mutation Research
Lucia LetavayováMiroslav Chovanec

Abstract

Selenium (Se) is a chemo-preventive agent that has been shown to have a protective role against cancer. The inorganic form of Se, sodium selenite (Na2SeO3), has frequently been included in various chemo-prevention studies, and this commercially available form of Se is used as dietary supplement by the public. Because high doses of this Se compound can be toxic, the underlying molecular mechanisms of sodium selenite toxicity need to be elucidated. Recently, we have reported that sodium selenite is acting as an oxidizing agent in the budding yeast Saccharomyces cerevisiae, producing oxidative damage to DNA. This pro-oxidative activity of sodium selenite likely accounted for the observed DNA double-strand breaks (DSB) and yeast cell death. In this study we determine the genetic factors that are responsible for repair of sodium selenite-induced DSB. We report that the Rad52 protein is indispensable for repairing sodium selenite-induced DSB, suggesting a fundamental role of homologous recombination (HR) in this repair process. These results provide the first evidence that HR may have a fundamental role in the repair of sodium selenite-induced toxic DNA lesions.

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Citations

Dec 25, 2009·Archives of Toxicology·Vanessa ValdiglesiasBlanca Laffon
Sep 28, 2010·Archives of Toxicology·Jela BrozmanováMiroslav Chovanec
Jul 4, 2012·Chemical Research in Toxicology·Dominika MánikováMiroslav Chovanec
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Jan 24, 2013·PloS One·Marc DauplaisPierre Plateau
Aug 16, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominika MánikováMiroslav Chovanec
Jul 6, 2014·Microbiological Research·Gustavo SantoyoMa Del Carmen Orozco-Mosqueda
May 12, 2009·Mutation Research·Javier Espinosa-AguirreRafael Camacho-Carranza
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Jun 3, 2017·Biomolecular Concepts·Myriam LazardPierre Plateau
Jun 3, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Fu-Jun LiuPatricia L Opresko

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