PMID: 2113569Apr 1, 1990Paper

Radial component of CNS myelin: junctional subunit structure and supramolecular assembly

Journal of Neurocytology
B Kosaras, D A Kirschner

Abstract

The radial component is a structural specialization within CNS myelin that is believed to stabilize the apposition of membranes in the internode. Previous observations on thin sections and freeze-fracture replicas show that this junctional complex consists of linear, particulate strands that run parallel to the nerve fibre axis and radially through the myelin sheath, but details on its molecular organization are lacking. The objective of our current study was to gain further insight into its arrangement and composition by examining its fine-structure and incidence in: myelin with known deficits in protein composition (e.g., shiverer, transgenic shiverer, myelin deficient and jimpy mutant mice); isolated CNS myelin, which has been shown by X-ray diffraction to be more stable than intact CNS myelin; and human white matter, in which this junctional complex has not yet been described. Our results confirm the localization and general appearance of the radial component as previously reported. In addition, we found that: (1) the radial component occurs abundantly in human CNS myelin where it has a complex subunit structure; (2) the constituent junctional unit of this structure is organized as a pair of globular domains (each approxima...Continue Reading

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Citations

Jun 1, 1994·Cell and Tissue Research·K Meller
Jan 1, 1996·Journal of Neurocytology·J KarthigasanD A Kirschner
Mar 1, 1993·Progress in Neurobiology·C HildebrandC Bjartmar
May 1, 2008·Neuron Glia Biology·Daniel A KirschnerHideyo Inouye
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lillian S DeBruinGeorge Harauz
May 3, 2011·World Journal of Radiology·Charles F BellowsGuiseppe Gagliardi
Oct 30, 2013·Cellular and Molecular Life Sciences : CMLS·Mostafa BakhtiMikael Simons
Jul 1, 1991·Journal of Neurochemistry·M I AveldañoJ Monreal
Oct 9, 2015·Biophysical Journal·Andrew R DenningerDaniel A Kirschner
Feb 13, 2013·Journal of Neurochemistry·George Harauz, Joan M Boggs
Sep 1, 1995·Medical Hypotheses·J KarthigasanD A Kirschner
Mar 25, 2015·Free Radical Biology & Medicine·Adrienne M LuomaDaniel A Kirschner
Oct 26, 2000·Protein Expression and Purification·I R BatesG Harauz
Nov 15, 1996·Structure·D A KirschnerR A Saavedra
Jun 28, 2006·Glia·Jack RosenbluthRolf Schiff
Mar 1, 1994·Journal of Neurochemistry·J KarthigasanD A Kirschner
Oct 13, 2006·Neurochemical Research·Lillian S Debruin, George Harauz
Apr 1, 1994·Journal of Neuroscience Research·A GowR A Lazzarini

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