PMID: 6970793Jan 1, 1981Paper

Radial forces within muscle fibers in rigor

The Journal of General Physiology
D W Maughan, R E Godt

Abstract

Considering the widely accepted cross-bridge model of muscle contraction (Huxley. 1969. Science [Wash. D. C.]. 164:1356-1366), one would expect that attachment of angled cross-bridges would give rise to radial as well as longitudinal forces in the muscle fiber. These forces would tend, in most instances, to draw the myofilaments together and to cause the fiber to decrease in width. Using optical techniques, we have observed significant changes in the width of mechanically skinned frog muscle fibers when the fibers are put into rigor by deleting ATP from the bathing medium. Using a high molecular weight polymer polyvinylpyrrolidone (PVP-40; number average mol. wt. (Mn) = 40,000) in the bathing solution, we were able to estimate the magnitude of the radial forces by shrinking the relaxed fiber to the width observed with rigor induction. With rigor, fiber widths decreased up to approximately 10%, with shrinking being greater at shorter sarcomere spacing and at lower PVP concentrations. At higher PVP concentrations, some fibers actually swelled slightly. Radial pressures seen with rigor in 2 and 4% PVP ranged up to 8.9 x 10(3) N/m2. Upon rigor induction, fibers exerted a longitudinal force of approximately 1 x 10(5) N/m2 that was i...Continue Reading

References

Aug 1, 1977·Biophysical Journal·R E Godt, D W Maughan
Jan 5, 1977·Journal of Molecular Biology·R Craig
Jan 1, 1978·Circulation Research·F J JulianM R Sollins
Sep 1, 1976·The Journal of General Physiology·M Kawai, P W Brandt
Feb 15, 1976·Journal of Molecular Biology·E W April, D Wong
Jun 20, 1969·Science·H E Huxley
Feb 20, 1966·Journal of the American Chemical Society·M M Khan, A E Martell

❮ Previous
Next ❯

Citations

Mar 1, 1982·Pflügers Archiv : European journal of physiology·M R Berman, D W Maughan
May 22, 2013·The Journal of Physiological Sciences : JPS·Daisuke MiyashiroTakenori Yamada
May 31, 1996·Forensic Science International : Synergy·A VainE Vuori
Jan 1, 1985·Critical Reviews in Food Science and Nutrition·A AsgharT Yasui
Dec 15, 2010·PLoS Computational Biology·C David WilliamsThomas L Daniel
Nov 21, 2012·PLoS Computational Biology·C David WilliamsThomas L Daniel
Mar 6, 1999·Biochemical and Biophysical Research Communications·Y YoshikawaT Yamada
Oct 1, 1995·Matrix Biology : Journal of the International Society for Matrix Biology·A K Davis, S S Carlson
Jun 16, 2015·Journal of Theoretical Biology·Avleen Randhawa, James M Wakeling
Feb 15, 1984·Journal of Molecular Biology·I MatsubaraR M Simmons
Jul 15, 2006·The Journal of Physiological Sciences : JPS·Nao AkiyamaTakenori Yamada
Apr 30, 1998·Physiological Reviews·B M Millman
Oct 1, 1981·Pflügers Archiv : European journal of physiology·R E Godt, D W Maughan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.