Radial fundus autofluorescence in the periphery in patients with X-linked retinitis pigmentosa

Clinical Ophthalmology
Ken OginoNagahisa Yoshimura

Abstract

To describe the peripheral autofluorescence images and clinical features of patients with retinal dystrophy who showed radial fundus autofluorescence (FAF) at the posterior pole. The authors retrospectively reviewed pooled wide-field FAF images of 711 patients with retinal dystrophy and 56 family members. Eleven eyes of seven women exhibited radial FAF at the posterior pole. Wide-field FAF showed extension of the radial pattern to the periphery in all eyes except one. One woman showed radial hyper-FAF only in the periphery, not at the posterior pole. These eight individuals were X-linked retinitis pigmentosa patients or carriers. The tapetal-like reflex was not observed in their color fundus photographs. The peripheral visual field showed wedge-shaped restriction in some individuals. Wide-field FAF imaging can depict radial FAF not only at the posterior pole but also in the periphery in X-linked retinitis pigmentosa carriers. The authors therefore agree with previous reports that radial FAF may be a hallmark of X-linked retinitis pigmentosa.

Citations

Jul 19, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Jesse D SengilloStephen H Tsang
Mar 29, 2019·International Journal of Molecular Sciences·Kentaro KurataYoshihiro Hotta
Aug 25, 2020·Ophthalmic Genetics·Grecia Yael Ortiz-RamirezVianney Cortés-González
Mar 7, 2020·Ophthalmology and Therapy·Maria Vittoria CicinelliMaurizio Battaglia Parodi
Jan 1, 2020·International Journal of Retina and Vitreous·Akio OishiAkitaka Tsujikawa

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Methods Mentioned

BETA
genotyping
exome sequencing
transgenic

Software Mentioned

Optos

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