Radial modulation of single microbubbles

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Marcia EmmerNico de Jong

Abstract

Radial modulation imaging is a new promising technique to improve contrast-enhanced ultrasound images. The method is based on dual-frequency insonation of contrast agent microbubbles. A low-frequency (LF) pulse is used to modulate the responses of the microbubbles to a high-frequency (HF) imaging pulse. Inverting the LF pulse induces amplitude and phase differences in the HF response of contrast agent microbubbles, which can be detected using Doppler techniques. Although the technique has been successfully implemented, no consensus persists on parameter choice and resulting effects. In a separate study, "compression-only" behavior of coated microbubbles was observed. Compression-only behavior could be beneficial for radial modulation imaging. This was investigated using high-speed camera recordings and simulations. We recorded the vibrations of 78 single microbubbles in a dual-frequency ultrasound field. The results showed that the LF pulse induced significant compression-only behavior, which for microbubble sizes below and at HF resonance resulted in high radial amplitude modulation. It, however, also appeared that, for radial modulation imaging, microbubble size is more important than resonance and compression-only effects.

References

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Citations

Nov 18, 2011·The Journal of the Acoustical Society of America·Euan Barlow, Anthony J Mulholland
May 8, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Francois T H YuXucai Chen
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
Nov 18, 2011·The Journal of the Acoustical Society of America·Jeroen SijlMichel Versluis
Jul 7, 2012·Ultrasound in Medicine & Biology·Telli FaezNico de Jong
Sep 21, 2010·Ultrasound in Medicine & Biology·David MarescaAntonius F W van der Steen
Apr 17, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Pavel ShirkovskiyPhilippe Pernod
Feb 24, 2011·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Sven Peter NäsholmBjørn A J Angelsen
Jan 5, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Telli FaezNico de Jong
Nov 30, 2012·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Sven Peter Näsholm, Bjørn A J Angelsen
Mar 1, 2015·Ultrasound in Medicine & Biology·Tom van RooijKlazina Kooiman
Mar 14, 2017·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Tom van RooijKlazina Kooiman
Apr 6, 2011·Physics in Medicine and Biology·Chih-Hao ChengChih-Kuang Yeh
Jan 23, 2021·Pharmaceutics·Simone A G LangeveldKlazina Kooiman
Feb 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Simone A G LangeveldKlazina Kooiman

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