Abstract
Radial scars and complex sclerosing lesions of the breast are part of a group of "indeterminate" breast lesions, which are excised due to risk of coexistent carcinoma. The aim of this study was to assess rate of upgrade of these lesions to invasive and in situ carcinoma and to quantify the risk of development of subsequent cancer in women diagnosed with these lesions. A retrospective review of a prospectively maintained breast screening database was performed. All patients with radial scar identified at either core biopsy or final excision biopsy between January 2006 and July 2012 were identified. Full pathological reports for both core biopsy and final excision biopsy were reviewed. Patient outcomes were followed for a mean of 117.1 months. Of 451 B3 biopsies performed at our screening unit, 95 (22%) were found to have a radial scar or complex sclerosing lesion (CSL) on core needle biopsy. Within this group, 77 had no atypia on CNB, with 7 (9%) upgraded to invasive/in situ carcinoma on final excision. Of nine with definite atypia on CNB, 3 (33%) were upgraded. In those patients without atypia or malignancy on final excision, 7.5% developed cancer during 10-year follow-up. Patients with radial scar with atypia have a higher ris...Continue Reading
References
Apr 2, 2004·Statistics in Medicine·Jonathan TyrerJack Cuzick
Mar 16, 2005·The American Journal of Surgical Pathology·Tarik M Elsheikh, Jan F Silverman
Feb 28, 2006·Cancer·Melinda E SandersWilliam D Dupont
Jun 15, 2007·Annals of Surgical Oncology·Vance SohnTommy Brown
Feb 26, 2008·Breast Cancer Research and Treatment·Jena C BergLynn C Hartmann
Jun 21, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D M BuntingR M Watkins
Aug 11, 2012·Annals of Surgical Oncology·Lee J McGhanRichard J Gray
Apr 24, 2013·Breast Cancer Research and Treatment·Sarah A AronerRulla M Tamimi
Jul 16, 2014·PloS One·Mengmeng LvJianhua Zhao
Jul 4, 2016·The Breast : Official Journal of the European Society of Mastology·Alana R DonaldsonBenjamin C Calhoun
Aug 20, 2016·The Breast Journal·Elizabeth Tágide KalifeYihong Wang
Aug 17, 2017·AJR. American Journal of Roentgenology·Michael A Cohen, Mary S Newell
Mar 14, 2018·Breast Cancer Research and Treatment·Wendy Yen Yun ChouRebecca Aft
Jul 7, 2018·JAMA Oncology·Nora PashayanPaul D P Pharoah
Sep 15, 2018·The Breast Journal·Michela GiulianiRiccardo Manfredi
Nov 6, 2018·BMC Medical Imaging·Su Min HaHa-Yeon Oh
Nov 22, 2018·Breast Cancer Research and Treatment·Gelareh Farshid, Elizabeth Buckley
Feb 26, 2019·The Lancet Oncology·Mary Beth TerryRobert J MacInnis