Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial

Lancet
Marco ValgimigliMATRIX investigators

Abstract

The Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox (MATRIX) programme was designed to assess the comparative safety and effectiveness of radial versus femoral access and of bivalirudin versus unfractionated heparin with optional glycoprotein IIb/IIIa inhibitors in patients with the whole spectrum of acute coronary syndrome undergoing invasive management. Here we describe the prespecified final 1-year outcomes of the entire programme. MATRIX was a programme of three nested, randomised, multicentre, open-label, superiority trials in patients with acute coronary syndrome in 78 hospitals in Italy, the Netherlands, Spain, and Sweden. Patients with ST-elevation myocardial infarction were simultaneously randomly assigned (1:1) before coronary angiography to radial or femoral access and to bivalirudin, with or without post-percutaneous coronary intervention infusion or unfractionated heparin (one-step inclusion). Patients with non-ST-elevation acute coronary syndrome were randomly assigned (1:1) before coronary angiography to radial or femoral access and, only if deemed eligible to percutaneous coronary intervention after angiography (two-step inclusion), entered the antithrombin...Continue Reading

Citations

Nov 20, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Sanjit S Jolly, Marco Valgimigli
Jan 3, 2019·European Heart Journal·Dariusz DudekWilliam Wijns
Jan 4, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sung Gyun AhnJunghan Yoon
Mar 6, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hidenori KomiyamaPatrick W Serruys
Jul 6, 2019·Circulation. Cardiovascular Interventions·Marius Reto BiglerChristian Seiler
Aug 23, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Guillaume Marquis-GravelE Magnus Ohman
Oct 15, 2019·Expert Review of Cardiovascular Therapy·Joe AounTariq Bhat
Dec 29, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hector M Garcia-GarciaMarco Valgimigli
Sep 6, 2019·Journal of Neurointerventional Surgery·Joshua W OsbunGregory J Zipfel
Feb 25, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Babikir KheiriJoaquin E Cigarroa
Nov 8, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Issa KutkutRichard S Mangus
Jan 13, 2019·Aging·Felice GragnanoMarco Valgimigli
Aug 30, 2020·European Heart Journal·Jean-Philippe ColletUNKNOWN ESC Scientific Document Group
Oct 23, 2019·Journal of Clinical Medicine·Renato Francesco Maria ScaliseFrancesco Costa
May 9, 2019·Advances in Therapy·Katie LindenIan B A Menown
Dec 11, 2019·Journal of Neurointerventional Surgery·Robert M StarkeUNKNOWN Society of NeuroInterventional Surgery
Jun 4, 2020·Journal of Neurointerventional Surgery·Yangchun LiRobert M Starke
Jan 8, 2019·The Korean Journal of Internal Medicine·Yongcheol KimMyung Ho Jeong
Jun 20, 2019·Expert Review of Cardiovascular Therapy·Arturo CesaroPaolo Calabrò
Jul 11, 2020·Journal of the American Heart Association·Lucas Chun Wah FongColin Berry
Oct 8, 2020·European Heart Journal. Acute Cardiovascular Care·Marco Valgimigli, Felice Gragnano
Jan 30, 2021·Journal of the American College of Cardiology·Sergio LeonardiMarco Valgimigli
Feb 18, 2021·Journal of Neurointerventional Surgery·Isaac Josh AbecassisRobert M Starke
Mar 6, 2021·AJNR. American Journal of Neuroradiology·D Dornbos
Feb 20, 2021·JACC. Cardiovascular Interventions·Felice GragnanoUNKNOWN MATRIX Trial Investigators

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