PMID: 9527263Apr 4, 1998Paper

Radiation and chemotherapy instead of surgery for low infiltrative rectal adenocarcinoma: a prospective trial

Annals of Surgical Oncology
B M RossiA Lopes

Abstract

The objective of this prospective study was to determine the possibility of treatment based exclusively on chemotherapy and radiotherapy for patients with low infiltrative rectal tumors in an attempt to preserve sphincter function. Sixteen patients with rectal adenocarcinoma up to 3 cm above the pectineal line with initial indications for abdominoperineal resection (APR) were submitted to a 5040-cGy (28 x 180 cGy) radiotherapy dose and chemotherapy during the first 3 and last 3 days of radiotherapy, using 425 mg/m2/day of 5-fluorouracil (5FU) and 20 mg/m2/day of folinic acid. Levamisole was used at 150 mg/day for 3 consecutive days at 2-week intervals throughout the period of therapy. Patients with a complete response were not submitted to APR, but received additional brachytherapy for curative purposes with doses from 2000 to 3000 cGy. Patients with recurrence after a complete response, with partial response, or with no response were submitted to APR. Six patients (37.5%) presented a complete response, five (31.25%) presented a partial response, and five (31.35%) did not respond. The disease-free interval ranged from 1 to 34 months (mean = 11 months) among the six patients with complete response, and only one patient not submi...Continue Reading

References

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Citations

Jul 4, 2002·Annals of Surgical Oncology·Wilson T NakagawaAdemar Lopes
Feb 16, 2010·Acta Oncologica·Robert HughesRobert Glynne-Jones
Aug 4, 2018·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·James Chi-Yong NguChia-Che Chen
Nov 29, 2007·Diseases of the Colon and Rectum·R Glynne-JonesJ Meyrick-Thomas
Jun 9, 2009·Diseases of the Colon and Rectum·Heather B NeumanLarissa K Temple
Jul 15, 2015·World Journal of Gastroenterology : WJG·Wolfgang B GaertnerGenevieve B Melton
Oct 3, 1999·Seminars in Surgical Oncology·B D Minsky
Mar 23, 2011·ANZ Journal of Surgery·Gurpreet Singh-Ranger
May 11, 2013·Organic Letters·Kavita SharmaHarinath Chakrapani

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