Radiation Biology Irradiator Dose Verification Survey

Radiation Research
Kurt H PedersenLarry A DeWerd

Abstract

Interest in standardized dosimetry for radiobiological irradiators has expanded over the last decade. At a symposium held at NIST, "The Importance of Standardization of Dosimetry in Radiobiology", a set of 12 criteria necessary for adequate irradiation was developed by the authors. Here we report on our review of dosimetry methods from various peer-reviewed publications and found that none of them satisfied all 12 criteria set forth by the authors of the NIAD/NCI/NIST proceedings. The inadequate reporting of dosimetry methods in the literature raises questions regarding the accuracy of the dose delivered to animal test subjects and the resulting experimental results. For this reason, we investigated the level of accuracy of dose delivery in radiation biology studies. We performed an irradiator output verification study of 12 radiation biology laboratories (7 gamma and 5 X-ray units) using polymethyl methacrylate (PMMA) mouse phantoms and thermoluminescent dosimeters (TLDs) readouts at the University of Wisconsin Medical Radiation Research Center (UWMRRC). The laboratories housing each of these irradiators were asked to deliver specific doses to individual mouse phantoms. Simultaneously, mouse phantoms at the UWMRRC were irradia...Continue Reading

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Citations

Oct 14, 2016·International Journal of Radiation Biology·François TrompierLaurence Roy
Mar 9, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Colello BrunoJ F Pavoni
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Nov 30, 2018·Medical Physics·Nolan EsplenMagdalena Bazalova-Carter
Nov 7, 2019·Medical Physics·Coralie Le DeroffAnne-Marie Frelin-Labalme
Feb 6, 2020·Medical Physics·Akbar AnvariAmit Sawant
Aug 29, 2019·Medical Physics·Nolan EsplenMagdalena Bazalova-Carter
Jul 9, 2020·Physics in Medicine and Biology·Yuncheng ZhongStrahinja Stojadinovic
Aug 2, 2019·Radiation Oncology·Emma R BiglinKaren J Kirkby
Apr 17, 2019·Australasian Physical & Engineering Sciences in Medicine·Theresa V FeddersenMartin A Ebert
Mar 18, 2020·Physics in Medicine and Biology·Gareth PriceAndrew Robinson
Feb 28, 2018·International Journal of Radiation Oncology, Biology, Physics·Radhe MohanJacek Capala
Sep 13, 2021·International Journal of Radiation Oncology, Biology, Physics·Larry A DeWerd, Keith Kunugi

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